en Immunology Immunology مقاله مروری Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:2;"><span style="color:black">The dynamic interplay between cellular immunity and tumor cells is essential in cancer advancement and response to therapy. This updated, comprehensive review examines the intricate relationship between these components, focusing on the function of different subsets of immune cells in both innate and acquired immunity. A literature search was conducted to identify cytokines involved in tumor cell induction, using keywords such as cytokines, tumor cells, immune cells, and cancer. Relevant articles published between 2003 and 2024 were reviewed, and their data were summarized. The review highlights the different roles of immune cell subsets in coordinating immune responses against tumors. Tumor-associated macrophages (TAMs) And Myeloid-derived suppressor cells (MDSCs) often stimulate cancer growth and evasion of the immune system by suppressing effector cells. Eosinophils and natural killer (NK) cells contribute to tumor surveillance and cytotoxicity, while dendritic cells (DCs) recreate paramount function in T-cell activation and antigen presentation. The complement system and neutrophils contribute to immune regulation and tumor-associated inflammation. T lymphocytes, particularly antigen-presenting cells (APCs) and cytotoxic CD8+ T cells are central to acquired immunity and the anti-tumor immune response. This review highlights how cytokines interact with tumor cells and their role in cancer biology, paving the way for identifying improved prognostic and diagnostic factors. The compiled findings discuss valuable cytokines for a more effective diagnosis of tumors and an accurate prognosis prediction.</span></span></span></span></div> Cytokines, Tumor Cells, Cancer, Immunity Cells 84 101 http://ijbc.ir/browse.php?a_code=A-10-1105-3&slc_lang=en&sid=1 Seyed Ali Aghapour aghapou@gmail.com 100319475328460010831 100319475328460010831 No Neonatal & Children᾿s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Mehdi Torabizadeh torabizadeh@ajums.ac.ir 100319475328460010832 100319475328460010832 No Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Seyed Sobhan Bahreiny bahsobi@gmail.com 100319475328460010833 100319475328460010833 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Najmaldin Saki najmaldinsaki@gmail.com 100319475328460010834 100319475328460010834 No Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Ali Jalali Far alijalilfar@gmail.com 100319475328460010835 100319475328460010835 No Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Arshid Yousefi-Avarvand Arshid.yousefi5@gmail.com 100319475328460010836 100319475328460010836 No Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Kiana Dost Mohammad Ghasemi kianaghasemi2023@gmail.com 100319475328460010837 100319475328460010837 No Department of Medical Sciences, Lahijan Azad University of Medical Sciences, Lahijan, Gilan, Iran Mojtaba Aghaei mojtabaaghaei745@gmail.com 100319475328460010838 100319475328460010838 Yes Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Mehdi Abolhasani mahdiabolhasani.20@gmail.com 100319475328460010839 100319475328460010839 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mohammad Sharif Sharifani sharif2022@gmail.com 100319475328460010840 100319475328460010840 No School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Ehsan Sarbazjoda ehsan.sarbazjoda@gmail.com 100319475328460010841 100319475328460010841 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Moslem Javidan moslemjavidann@gmail.com 100319475328460010842 100319475328460010842 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran