en Adults Hematology & Oncology Adults Hematology & Oncology مقاله مروری Review Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:2;">Systemic Lupus Erythematosus (SLE) is one of these conditions that presents difficult hurdles since it is a multi-systemic autoimmune condition with a wide range of implications, including an increased risk of cancer among affected people. According to recent evidence, it has been revealed that the lymphoma rate in patients with SLE can be 4 to 7 times higher than that of the general population. This increased risk is to be emphasized through stringent and attentive screening and management as the mechanism of this risk is still under research. Therefore, this section discusses a case study and literature regarding SLE and lymphoma better to comprehend the intricate correlation between the two conditions. Here, we present the case of a 53-year-old male who was just diagnosed with SLE and also suffering from abdominal pain and distention, in which the diagnosis of lymphoma is made via serial investigations. This case, therefore, gives us a lesson on the fact that Lymphoma should be considered as one of the differential diagnoses in SLE patients presenting with abdominal complaints. With the ever-changing knowledge about the basic mechanisms of SLE and appropriate screening techniques, our attention to cancer risk in SLE patients should be increased to achieve better clinical outcomes.</span></span></span></div> Systemic Lupus Erythematosus, Lymphoma, Vasculitis, Autoimmune, Abdominal Manifestation 14 22 http://ijbc.ir/browse.php?a_code=A-10-1169-1&slc_lang=en&sid=1 Raja Adib Bakhsh rajaa_bakhsh09@outlook.com 100319475328460011277 100319475328460011277 Yes King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. Khaled Saleh Dairi Khaled_Saleh_Dairi12@outlook.com 100319475328460011278 100319475328460011278 No King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. Mohammad Hamid Alabdali mohammad_hamid_alabdali12@outlook.com 100319475328460011279 100319475328460011279 No King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. Sameer Mohammed Aljuhani SameerMohammedAljuhani@outlook.com 100319475328460011280 100319475328460011280 No King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. Rawan Khaled Altaib RawanKhaledAltaib15@outlook.com 100319475328460011281 100319475328460011281 No King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia. Mohammed Ahmed Hasaballah MohammedAhmedHasaballah@outlook.com 100319475328460011282 100319475328460011282 No King Faisal Hospital, Internal Medicine Department, 4588, Prince Majed ibn Abd Al Aziz, 7451, Al Maabdah, Makkah 24236, Saudi Arabia.