Iranian Journal of Blood and Cancer

en The Potential Role of microRNAs in the Progression and Aggressiveness of Gallbladder Cancer: Molecular Markers to Therapeutic Interventions Cancer Surgery Cancer Surgery مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;">Gallbladder cancer (GBC) is among the utmost pervasive form of biliary tract cancers and remains relatively under-researched. Its prognosis is generally poor, with survival rates varying based on diagnostic stage, from 20% to 65%. The hallmarks of cancer, such as proliferation of cells, migration of cells, invasion, process of programmed cell death, radio/chemosensitivity, and cancer stem cell phenotype, are all influenced by miRNAs, which have been found to be essential actuators in the process of gene expression. This review is an attempt to reveal the molecular pathways influenced by miRNAs that could be targeted for therapeutic purposes in gallbladder cancer (GBC) and also emphasizes the need for precision medicine to target potent pathways, utilizing not only inhibiting receptor or antibody but also investigating miRNAs as a potential treatment strategy.</span></span></span></div> Gallbladder cancer, MicroRNAs, Molecular Pathways, Target therapy, Promising biomarker 69 85 http://ijbc.ir/browse.php?a_code=A-10-1220-1&slc_lang=en&sid=1 Naseem Fatima naseemfatima.fatima@gmail.com 100319475328460011546 100319475328460011546 No Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India. Syed Tasleem Raza tasleem24@gmail.com 100319475328460011547 100319475328460011547 Yes Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow, India. Vijay Kumar drvkumar2007@gmil.com 100319475328460011548 100319475328460011548 No Department of Surgical Oncology, King George’s Medical University, Lucknow, India. Saliha Rizvi rizvi_saliha@rediffmail.com 100319475328460011549 100319475328460011549 No Department of Biotechnology, Era University, Lucknow, India Farheen Khan Farheenkh19@gmail.com 100319475328460011550 100319475328460011550 No Department of Biotechnology, Era University, Lucknow, India