en Radiotherapy Radiotherapy مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;">Cancer is estimated to overtake cardiovascular diseases and take the top spot as the leading and most important cause of mortality globally in the near future. Given the importance of early diagnosis to reduce mortality, many efforts have been made to discover a theranostic system for simultaneous cancer diagnosis and treatment. So far, the use of nanotechnology has greatly contributed to the improvement and development of these systems. Meanwhile, dendrimer nanoparticles have attracted considerable attention in medical research due to their unique properties. Poly(amidoamine) (PAMAM) dendrimers have become the primary category of dendrimers and have been widely studied for their possible application in cancer treatments. These nanoparticles have features including interior cavities and peripheral functional groups that allow the encapsulation of diverse medications or diagnostic agents. As a result, these particles can function as efficient nanocarriers and vectors for medical applications. This capability allows for the resolution of the obstacles presented by the tumor microenvironment. The prospective use of multifunctional PAMAM holds promise in enabling thorough monitoring of different stages of treated cancer tissue, hence providing substantial support in the early detection and prediction of tumor response. The primary focus of this study will be to investigate the most recent developments of PAMAM dendrimers in the field of cancer theranostics. The employment of NPs in anticancer medicine administration for radiation treatment, chemotherapy, and diagnostic imaging is underscored due to its significant potential.</span></span></span></div> PAMAM dendrimers, Chemotherapy, Radio sensitization, Imaging 86 104 http://ijbc.ir/browse.php?a_code=A-10-932-2&slc_lang=en&sid=1 Mahdieh Ahmadi Kamalabadi mkniloo@yahoo.com 100319475328460011656 100319475328460011656 No Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Somayeh Kazempour skazempour.sunny@gmail.com.com 100319475328460011657 100319475328460011657 No Department of Radiology, Faculty of Allied Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Asieh Fatemidokht a_fatemidokht@yahoo.com 100319475328460011658 100319475328460011658 No Department of Radiology, Faculty of Allied Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Mikaeil Molazadeh 100319475328460011659 100319475328460011659 No Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Fereshteh Koosha frshtkoosha@yahoo.com 100319475328460011660 100319475328460011660 Yes Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.