en Immunology Immunology مقاله مروری Review Article <p style="text-align:justify"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:2;">A number of variables may influence the development and spread of lung cancer (LC), one of the most prevalent and fatal cancers in the world. In this context, viruses are important, especially the human papillomavirus (HPV), Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), influenza virus (IV), and cytomegalovirus (CMV). These viruses can influence the development of LC through metabolic alterations, immune response suppression, and disruption of the tumor microenvironment (TME). Specifically, HPV may contribute to LC through genetic effects, while EBV can induce molecular changes in cells. HIV, by suppressing the immune system and increasing the risk of secondary infections, may create conditions conducive to the development of lung tumors. IV and CMV can also play a role in accelerating tumorigenic processes by impacting the immune system and promoting inflammation. This review article examines the various mechanisms by which viruses are involved in LC and their association with the progression of lung tumors. Additionally, the role of vaccination in preventing LC, particularly in individuals infected with specific viruses, is explored.</span></span></span></p> Pulmonary neoplasms, Human papillomavirus,Epstein-Barr virus, Human immunodeficiency virus, Influenza virus, Cytomegalovirus 91 97 http://ijbc.ir/browse.php?a_code=A-10-1710-1&slc_lang=en&sid=1 Abolfazl Jafari-Sales a.jafari_1392@yahoo.com 100319475328460011881 100319475328460011881 No Department of Microbiology, Kaz.C., Islamic Azad University, Kazerun, Iran. Elham Nozohour-Leilabadi elhamnozohour80@gmail.com 100319475328460011882 100319475328460011882 No Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran. Maryam Safari maryamsafari1381@gmail.com 100319475328460011883 100319475328460011883 No Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran. Maryam Farahnaki-Sadabadi maryamfarahnaki.2004@gmail.com 100319475328460011884 100319475328460011884 No Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran. Negin Yaghoubi-Azar Negin.yagoobi@gmail.com 100319475328460011885 100319475328460011885 No Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran. Mehrdad Pashazadeh mehrdadpashazadeh85@gmail.com 100319475328460011886 100319475328460011886 Yes Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran.