Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1388
11
1
gregorian
2010
2
1
2
2
online
1
fulltext
en
Molecular Markers in Neuroblastoma
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
Neuroblastoma, one of the common malignant childhood tumors, arises from neuroblast cells derived from the<br>neural crest and destined for the adrenal medulla and the sympathetic nervous system and shows remarkable biological<br>heterogeneity, resulting in favorable or unfavorable outcomes. Some tumors make rapid progress with a fatal<br>outcome. In other instances, the tumors regress spontaneously in infants or to differentiate into a benign ganglioneuroma<br>in older patients. This heterogeneity within neuroblastoma depends on the molecular characteristics of tumor<br>cells. Several distinct genomic alterations have been found in neuroblastoma, including MYCN amplification, DNA<br>ploidy, deletion of the short arm of chromosome 1, gain of chromosome 17q, and deletion of 11q. The difference of<br>expression was also found in genes related to cellular growth, differentiation, and apoptosis of neural network including<br>signaling by NTRK1 or ALK receptor tyrosine kinases, and telomerase activity. And this presentation discusses<br>diagnostic and prognostic molecular makers for extensive heterogeneity of neuroblastoma. This should lead to more<br>risk-adapted therapies according to the genetic markers by which individual neuroblastomas are biologically characterized.
Neuroblastoma, Prognosis, MYCN, Ploidy, Chromosome, Telomerase, Telomere, Apoptosis
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http://ijbc.ir/browse.php?a_code=A-10-2-170&slc_lang=en&sid=1