Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61882/ijbc
14
2008-4595
13
en
jalali
1404
3
1
gregorian
2025
6
1
17
2
online
1
fulltext
en
Natural killer cell-based Immunotherapy for Solid tumors: A Comprehensive Review
Adults Hematology & Oncology
Adults Hematology & Oncology
مقاله مروری
Review Article
<div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;">Natural Killer Celle (NK) are innate immune cells with potent cytotoxic activity against tumor cells, making them attractive candidates for cancer immunotherapy. While NK cell-based therapies have shown promise in hematologic malignancies, their efficacy against solid tumors remains challenging due to the immunosuppressive tumor microenvironment (TME) and limited NK cell persistence. This review discusses recent advances in NK cell-based immunotherapies, including adoptive NK cell transfer, NK cell engagers, and genetic modifications to enhance their anti-tumor activity. We also explore the barriers to effective NK cell therapies in solid tumors and potential strategies to overcome these limitations.</span></span></span></div>
Natural Killer (NK) Cells, Adoptive NK Cell Transfer, Tumor Microenvironment, Immunosuppressive Factors
83
98
http://ijbc.ir/browse.php?a_code=A-10-2005-1&slc_lang=en&sid=1
Vinod Kumar
Singh
drvinodkumarsingh85@gmail.com
100319475328460012193
100319475328460012193
Yes
TMMC&RC, Teerthanker Mahaveer University, Moradabad, UP, India.
Seema
Awasthi
100319475328460012194
100319475328460012194
No
TMMC&RC, Teerthanker Mahaveer University, Moradabad, UP, India.
Sonika
Sharma
100319475328460012195
100319475328460012195
No
TMMC&RC, Teerthanker Mahaveer University, Moradabad, UP, India.