Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1388
4
1
gregorian
2009
7
1
1
4
online
1
fulltext
en
Antineoplastic Effect of Fenugreek (Trigonella Foenum Graecum) Seed Extract against Acute Myeloblastic Leukemia Cell Line (KG-1)
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
<p><strong>Background</strong>: Treatment of cancer patients using conventional chemotherapy causes serious side effects and, at best, merely extends the patient’s lifespan by a few years. The potential of alternative therapies may therefore be of great benefit in cancer control. The effect of Trigonella Foenum Graecum seed extract has been previously reported on some neoplastic cells. Here, its effect is evaluated on human acute myeloblastic leukemia cell lines. </p><p><strong>Materials and Methods:</strong> The cell line KG-1 was treated with various concentrations of Fenugreek seeds extract with various durations. Cellular enumeration, viability test, staining and light microscopy, and apoptosis induction were evaluated. </p><p><strong>Results:</strong> Results showed significant cytotoxic effect of Fenugreek seeds extract against this cell line which resulted in growth inhibition, cell death and morphological changes. Apoptosis induction was not considerable. Fenugreek seeds extract did not change the count and morphology of normal lymphocytes. </p><p><strong>Conclusion:</strong> Applying herbal medicines could be an effective and safe treatment for leukemia. To our knowledge, this is the first study that suggests significant chemotherapeutic effects of Fenugreek seeds against these cell lines.</p>
Trigonella, Acute myeloblastic leukemia, Apoptosis
139
146
http://ijbc.ir/browse.php?a_code=A-10-2-3&slc_lang=en&sid=1
Shaban
Alizadeh
100319475328460086
100319475328460086
Yes
Seyed Abdol-Hamid
Jahanmehr
100319475328460087
100319475328460087
No
Ali Reza
Ardjmand
100319475328460088
100319475328460088
No
Mostafa
Rezaian
100319475328460089
100319475328460089
No
Hosein
Dargahi
100319475328460090
100319475328460090
No
Nahid
Einolahi
100319475328460091
100319475328460091
No
Monireh
Sadrossadat
100319475328460092
100319475328460092
No