Iranian Journal of Blood and Cancer
Iranian Journal of Blood and Cancer
Medical Sciences
http://ijbc.ir
1
admin
2008-4595
2008-4609
8
10.61186/ijbc
14
2008-4595
13
en
jalali
1390
9
1
gregorian
2011
12
1
4
1
online
1
fulltext
en
Frequency of Decreased Bone Mineral Density and Its Risk Factors during Childhood among Iranian Hemophilia Patients
Pediatric Hematology & Oncology
Pediatric Hematology & Oncology
پژوهشي
Original Article
This study was undertaken to assess the frequency of decreased bone mineral density and its risk factors as well as its impact on the quality of life during childhood among hemophiliac patients.
Materials and Methods: Thirty seven children with severe hemophilia A and B, referred to Mofid Children’s Hospital during 2010, were selected. For all patients the joint score, body mass indexes, bone mineral density, the level of inhibitor antibodies were measured. Short forms of Haeamo-QoL questionnaire were used to assess their quality of life. Data were statistically analyzed using Kolmogorov-Smirnov Z, Mann-Whitney, T-test, Fisher’s eact test, and χ² test.
Results: In this study the overall prevalence of low bone density was 35%. Factors that were significantly associated with the frequency and severity of decreased bone density were age, presence of inhibitor antibodies, and reduced joint range of motion. Total quality of life score, and the sub scores of “viewpoint” and “others” as well as the “attitude” were decreased significantly in patients with decreased bone density.
Conclusion: According to our findings there is a high prevalence of low bone density among hemophiliac patients. The body mass index should be maintained by appropriate nutrition and exercise to prevent loss of bone density in patients with hemophilia. Prophylaxis regimen in early childhood and regular monitoring of inhibitor antibody development are advised for early detection and management of this complication.
Key words: Hemophilia, antibody, body mass index, bone mineral density, quality of life
Hemophilia, antibody, body mass index, bone mineral density, quality of life
13
17
http://ijbc.ir/browse.php?a_code=A-10-9-11&slc_lang=en&sid=1
Peyman
Eshghi
peyman64@yahoo.com
10031947532846001274
10031947532846001274
Yes
Pediatric Congenital Hematologic Disorders Research Center/Shahid Beheshti University of Medical Sciences
Borhan
Moradveisi
10031947532846001275
10031947532846001275
No
Department of Pediatric Faculty of Medicine/Kurdistan University of Medical Sciences