Thromboembolic Events in Severe Thalassemia Syndromes

Hashemieh, Mozhgan

Volume 12, Issue 2 ( June 2020 2020) Iranian Journal of Blood and Cancer 2020, 12(2): 41-46 | Back to browse issues page

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Hashemieh M. Thromboembolic Events in Severe Thalassemia Syndromes. Iranian Journal of Blood and Cancer 2020; 12 (2) :41-46
URL: http://ijbc.ir/article-1-939-en.html

Thromboembolic Events in Severe Thalassemia Syndromes

Mozhgan Hashemieh ^*

Imam Hossein Medical Center, Shahod Beheshti University of Medical Sciences, Tehran, Iran. , m.hashemieh@sbmu.ac.ir

Abstract: (3428 Views)

In the last few decades, the prognosis of patients with β-thalassemia has improved dramatically. However these patients suffer from many serious complications. One of the most important morbidities in patients with thalassemia are thromboembolic events that are mainly observed in thalassemia intermedia. Profound hemostatic changes have been observed in patients with thalassemia intermedia and numerous factors have been attributed to the pathogenesis of hypercoagulable state among patients with thalassemia intermedia. In this review the different mechanisms resulting in hypercoagulability in patients with thalassemia, the clinical importance, prevention and treatment of thromboembolic episodes have been discussed.

Keywords: Thalassemia major, Thalassemia intermedia, Thrombosis, Hypercoagulability, Thromboembolic events, Platelets, Red blood cells, Adhesion molecules

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: Review Article | Subject: Pediatric Hematology & Oncology
Received: 2019/09/28 | Accepted: 2020/04/17 | Published: 2020/08/13

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