Review of endocrine complications in transfusion-dependent thalassemia
Major Beta thalassemia is a genetic disorder that often results in transfusion dependence and increased iron accumulation in the body. This iron overload can lead to tissue damage in various organs, including the heart, liver, and endocrine systems. Endocrine problems are a common complication in transfusion-dependent thalassemia, and addressing these issues can significantly improve patient's quality of life. The prevalence of endocrinopathy is high, particularly in patients with poor therapy compliance. The most common endocrine disorders include hypogonadism, growth disturbances, short stature, delayed puberty, acquired hypothyroidism and hypoparathyroidism, adrenal dysfunction, osteoporosis, diabetes, fertility issues, and complications during pregnancy. Early diagnosis and treatment of endocrine disorders can improve patients' quality of life and reduce social problems. Faranoush and colleagues conducted a thorough investigation of the various endocrine complications observed in individuals with thalassemia in the current review.The full-text of their article is available for download here.
From viral encounter to leukemic challenge: a case of isolated molecular relapse in a child with acute promyelocytic leukemia after SARS-CoV-2 infection
Abdolkarimi et al. presented a case study on a pediatric patient diagnosed with APL who suffered from a cerebral ischemic stroke. It is noteworthy that this stroke occurred following a SARS-CoV-2 infection, specifically during an isolated molecular relapse. The significance of this study is heightened due to the extensive research conducted on the neurological complications associated with COVID-19. Additionally, the authors elucidated the mechanism through which SARS-CoV-2 can invade the nervous system and potentially induce neurological harm. The full-text of their article is available for download here.
Younesian et al. conducted a comprehensive review of current research examining the biological role of genes associated with the SCN and the effects of genetic mutations on the pathogenesis of neutropenia. Their primary objective was to elucidate the underlying mechanisms that contribute to the development of SCN-related disorders, with a particular emphasis on mutations in SCN1 to SCN9 and X-linked SCN (XSCN). The authors' detailed analysis sheds light on the complex interplay between genetic factors and disease pathophysiology.
The full-text of their article is available for download here, providing a valuable resource for further investigation into this important area of medical research.
- Year 2024
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- Harnessing the Power of MAGE Proteins in Cancer Immunotherapy for Multiple Myeloma
Mahsa Sohani, Amirhossein Rastgar, Setare Kheyrandish * - Ikaros (IKZF1): From Normal Hematopoiesis to Hematologic Malignancies
Hamed Baghdadi, Mehdi Shakouri Khomartash, Nazanin Ahmadi, Ali Faridfar, Mahdi Ghorbani * - Antibiotic-Induced Obesity in Childhood Acute Lymphoblastic Leukemia: An Intricate Network of Antibiotic-Microbiome-Obesity
Bita Bandar, Alireza Mohebbi, Najmaldin Saki, Arshid Yousefi-Avarvand * - Guideline for the Diagnosis and Management of Growth and Puberty Disorders in Patients with Transfusion-Dependent Thalassemia
Fariba Ghassemi, Mohammad E. Khamseh, Negin Sadighnia, Mojtaba Malek, Nahid Hashemi-madani, Neda Rahimian, Pooya Faranoush, Ali Elahinia, Vahid Saeedi, Dorsa Fallah Azad, Mohammad Faranoush * - Guideline for Diagnosis and Treatment of Osteoporosis in Transfusion-Dependent Thalassemia Patients
Mojtaba Malek, Mohammad E. Khamseh, Pooya Faranoush, Nahid Hashemi-madani, Neda Rahimian, Fariba Ghassemi, Mohammad Reza Foroughi-Gilvaee, Negin Sadighnia, Ali Elahinia, Mohammad Reza Rezvany, Dorsa Fallah Azad, Mohammad Faranoush * - Plasma Production in Iran: Streaming Towards Plasma Self-sufficiency
Zahra Ghasemi, Hassan Abolghasemi, Fatemeh Babaei, Abdol Majid Cheraghali, Nazila Yousefi * - Methylation Dynamics of the PPAR Gamma (PPARγ) Gene during Adipogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
Saeid Kaviani, Aryan Salahi-Niri, Mohammad Hossein Mohammadi, Mohsen Hamidpour, Shadi Esmaeili * - The Influence of Extracellular Vesicles from Human Peripheral Blood Mononuclear Cells and Umbilical Cord Mesenchymal Stem Cells on Acute Lymphoid Leukemia Cells
Hajar Mardani Valandani, Amir mohammad zahedi, Roohollah Mirzaee Khalilabadi * - Docosahexaenoic Acid (DHA) Impairs Docetaxel-Induced Up-regulation of miR-30a-5p and miR-126-5p Tumor Suppressors in Gastric Cancer Cell Line
Najibeh Shekari, Hajar Abbasi-Kenarsari, Behzad Baradaran, Tohid Kazemi * - Cervical Cancer Screening in Southern Iran: Understanding Prevalence and Predictors through the Health Belief Model Approach
Ali Torabi Nejad Kermani, Zohreh Torabi Nejad Kermani, Farshid Sharifi, Mina Danaei, Mohsen Momeni *
Recent research indicates that microbes may have a significant impact on the development of cancer. The interaction between microbes and the host's immune system, known as the immuno-oncology-microbiome (IOM) axis, is a common theme in microbial involvement in cancer. Scientists are exploring different approaches to manipulate the gut or tumor microbiome as potential treatments for cancer. Studies suggest that the gut microbiome can affect the effectiveness of cancer immunotherapy, and it may be possible to engineer certain bacteria to target cancerous growths. Future research in this field will likely focus on further investigating the IOM axis and developing targeted therapies that manipulate the microbiome to improve cancer outcomes.
The Iranian Journal of Blood and Cancer (IJBC) has organized a special issue to gather original research and review articles that explore the latest advancements and emerging trends regarding the role of the microbiome in cancer. By presenting the most significant contributions in this area, this issue aims to deepen our understanding of how the microbiome can trigger cancer and how these small microorganisms can impact the treatment of different types of cancer.
SUBMISSION DEADLINE: 1 April 2024
Journal Information
- Journal Title: Iranian Journal of Blood and Cancer
- Publisher: Iranian Pediatric Hematology & Oncology Society
- Print ISSN: 2008-4595
- Online ISSN: 2008-4609
- Release interval: Quarterly
- Journal language: English
- Chairman: Dr. Mohammad Saeid Rahiminejad
- Editor-in-Chief: Dr. Hassan Abolghasemi
- Associate Editors: Dr.Davood Bashash; Dr. Mohammad Faranoosh
- Executive Editor: Amir-Mohammad Yousefi
- Current Issue: 2024، Volume 16، Number 1
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