Subcutaneous Hematoma as an Unusual Presentation of Chronic Myelogenous Leukemia following Bone Marrow Aspiration: A Case Report and Narrative Review

Mashategan, Pourya; Abolghasemi, Hassan; Emami Meibodi, Mohammad Kazem

Volume 17, Issue 3 (September-2025 2025) Iranian Journal of Blood and Cancer 2025, 17(3): 1-4 | Back to browse issues page

Mendeley

Zotero

RefWorks

Mashategan P, Abolghasemi H, Emami Meibodi M K. Subcutaneous Hematoma as an Unusual Presentation of Chronic Myelogenous Leukemia following Bone Marrow Aspiration: A Case Report and Narrative Review. Iranian Journal of Blood and Cancer 2025; 17 (3) :1-4
URL: http://ijbc.ir/article-1-1763-en.html

Subcutaneous Hematoma as an Unusual Presentation of Chronic Myelogenous Leukemia following Bone Marrow Aspiration: A Case Report and Narrative Review

Pourya Mashategan¹

, Hassan Abolghasemi ^*²

, Mohammad Kazem Emami Meibodi³

1- Department of Pediatrics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2- Department of Pediatrics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. , HassanAbol@Yahoo.com
3- Department of Orthopedics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Abstract: (57 Views)

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the BCR-ABL1 fusion gene, also known as the Philadelphia chromosome. Bleeding complications are uncommon in the chronic phase of CML due to preserved platelet function. However, rare cases of subcutaneous hematoma have been reported in association with factor XIII deficiency or other coagulopathies. We report the case of a 19-year-old adolescent diagnosed with CML who developed a subcutaneous hematoma after bone marrow aspiration. The patient presented with localized swelling and tenderness at the aspiration site, which was later confirmed as a hematoma on imaging. Laboratory tests revealed a preserved platelet count, but suggested a possible underlying coagulopathy. Further investigation revealed a factor XIII deficiency contributing to the unusual presentation. This case highlights the importance of considering rare bleeding disorders, such as factor XIII deficiency, in patients with CML who present with unusual bleeding manifestations. Early recognition and management of such complications are critical for optimal patient outcomes.

Keywords: Chronic myeloid leukemia, Subcutaneous hematoma, Bleeding complications, Factor XIII deficiency, BCR-ABL fusion gene, Bone marrow aspiration

Full-Text [PDF 434 kb] (46 Downloads)

: Case report | Subject: Pediatric Hematology & Oncology
Received: 2025/07/4 | Accepted: 2025/09/24 | Published: 2025/09/30

Send email to the article author

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb