Volume 17, Issue 3 (September-2025 2025)                   Iranian Journal of Blood and Cancer 2025, 17(3): 79-95 | Back to browse issues page

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Kumar Singh V, Singh Matreja P, Singh S, Awasthi S. The Immune Microenvironment in Acute Myeloid Leukemia: Mechanisms of Immune Evasion and Emerging Therapeutic Strategies. Iranian Journal of Blood and Cancer 2025; 17 (3) :79-95
URL: http://ijbc.ir/article-1-1779-en.html
The Immune Microenvironment in Acute Myeloid Leukemia: Mechanisms of Immune Evasion and Emerging Therapeutic Strategies
Vinod Kumar Singh *1 , Prithpal Singh Matreja2 , Sudhir Singh3 , Seema Awasthi4
1- Department of General Medicine, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India. , drvinodkumarsingh85@gmail.com
2- Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
3- Department of microbiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
4- Department of pathology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Abstract:   (43 Views)
Acute Myeloid Leukemia (AML), a diverse type of blood cancer, is characterized by the unchecked multiplication of myeloid precursor cells within a disrupted bone marrow microenvironment (BMM). Leukemic blasts alter the BMM to create a leukemia niche, promoting immunological evasion and disease development. High relapse rates highlight the need for novel therapeutic approaches, even if chemotherapy is still the cornerstone of treatment. AML cells use many strategies to avoid immune identification, such as suppressing anti-leukemic immune responses and upregulating immune checkpoints. Immunotherapies like checkpoint inhibitors that target these pathways have shown encouraging promise. The intricate relationships between AML and the immunological milieu are examined in this review, with a focus on immune evasion, treatment resistance, and innovative immunotherapeutic strategies to improve anti-leukemic immunity.
Keywords: Acute Myeloid Leukemia, Hematological malignancies, Cytogenetics
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: Review Article | Subject: Adults Hematology & Oncology
Received: 2025/07/21 | Accepted: 2025/09/11 | Published: 2025/09/30
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