Review of endocrine complications in transfusion-dependent thalassemia

Faranoush, Pooya; Elahinia, Ali; Ziaee, Amir; Faranoush, Mohammad

Volume 15, Issue 4 (September 2023 2023) Iranian Journal of Blood and Cancer 2023, 15(4): 212-235 | Back to browse issues page

Mendeley

Zotero

RefWorks

Faranoush P, Elahinia A, Ziaee A, Faranoush M. Review of endocrine complications in transfusion-dependent thalassemia. Iranian Journal of Blood and Cancer 2023; 15 (4) :212-235
URL: http://ijbc.ir/article-1-1401-en.html

Review of endocrine complications in transfusion-dependent thalassemia

Pooya Faranoush¹, Ali Elahinia¹, Amir Ziaee¹, Mohammad Faranoush ^*²

1- Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran-Iran
2- Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran-Iran , faranoush47@gmail.com

Abstract: (55 Views)

Beta thalassemia is an inherited genetic disorder that often leads to transfusion dependence. One of the significant issues that these patients face is increased iron accumulation in their bodies due to the nature of the disease and regular blood transfusions. Iron overload can cause hemosiderosis and tissue damage in various organs, including the heart, liver, and endocrine systems. Endocrine problems are one of the most common complications in transfusion-dependent thalassemia, and addressing these complications can significantly improve patients' health-related quality of life. The prevalence of endocrinopathy is high, especially in patients with poor compliance with therapy. The most common endocrine disorders include hypogonadism, growth disturbances, short stature, delayed puberty, acquired hypothyroidism and hypoparathyroidism, adrenal dysfunction, osteoporosis, diabetes, fertility issues, and complications during pregnancy. Timely diagnosis and treatment of endocrine disorders can improve patients' quality of life and reduce social problems. This article reviews the literature on the various endocrine complications encountered in thalassemia.

Keywords: Iron overload, Endocrinopathy, Thalassemia, Blood transfusion

Full-Text [PDF 7941 kb] (54 Downloads)

: Review Article | Subject: Pediatric Hematology & Oncology
Received: 2023/06/23 | Accepted: 2023/08/22 | Published: 2023/09/17

Send email to the article author

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb