[Home ] [Archive]    
:: Home :: About Journal :: Registration :: Article Submission :: Contact us :: Site Map ::
:: Volume 11, Issue 4 (December 2019 2019) ::
IJBC 2019, 11(4): 123-126 Back to browse issues page
Assessment of Association between Duffy Blood Group Phenotypes and Susceptibility to Systemic Lupus Erythematosus and its Severity
Alireza Rezvani, Reza Fakhar, Ehsan Taherifard, Zahra Habibagahi, Erfan Taherifard *
Medical student at Shiraz University of Medical Sciences, Shiraz, Fars, Iran
Abstract:   (640 Views)
Background: Considering the role of Duffy antigenic system expression on RBCs as chemokines for inflammatory cytokines, expression of Duffy antigens as different phenotypes was studied in a group of patients with SLE. The association between different phenotypes of Duffy antigens and occurrence of SLE and its severity was assessed. 
Methods: This cross-sectional study was carried out on 100 patients diagnosed as SLE using the “Systemic Lupus International Collaborating Clinics 2012 (SLICC) classification” criteria and 100 age-matched healthy subjects as control from April to June 2017. Duffy blood group status was determined in both groups. The patients were categorized into three groups of mild, moderate and severe according to “Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K)” scores.
Results: The results of this study showed no significant association between the three different phenotypes of Duffy antigen system and increased risk of SLE or its severity.
Conclusion: The results of the current study did not approve of any association between three different Duffy phenotypes and increased risk of SLE or its severity. 
Keywords: Systemic lupus erythematosus, Duffy blood group system, DARC antigen, Blood group antigens, Association
Full-Text [PDF 453 kb]   (150 Downloads)    
: Research | Subject: Immunology
Received: 2019/07/16 | Accepted: 2019/12/13 | Published: 2020/01/27
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rezvani A, Fakhar R, Taherifard E, Habibagahi Z, Taherifard E. Assessment of Association between Duffy Blood Group Phenotypes and Susceptibility to Systemic Lupus Erythematosus and its Severity. IJBC. 2019; 11 (4) :123-126
URL: http://ijbc.ir/article-1-914-en.html


Volume 11, Issue 4 (December 2019 2019) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4106