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:: Volume 12, Issue 3 (September 2020 2020) ::
IJBC 2020, 12(3): 75-79 Back to browse issues page
What We Know of the Prognostic Value of Lymphopenia in SARS-CoV-2 Infection
Atieh Pourbagheri-Sigaroodi Miss, Davood Bashash *, Meysam Olfatifar, Sina Salari, Hassan Abolghasemi
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (945 Views)
Background: Although by comparing the number of deaths to the total number of cases one may conclude that most of the infected cases are recovering, taking a look at the increasing statistics of deaths shows that SARS-CoV-2 continues to take its toll. Since lymphocytes are the main immune cells battling with rapidly evolving viruses, it comes as no surprise to assume that a decreased number of these propitious soldiers may contribute to poor prognosis of the wide range of viral infections, including COVID-19. 
Methods: To provide a better prospect representing the prognostic value of lymphopenia in COVID-19, we searched the national library of medicine Medline/PubMed and performed a meta-analysis of pertinent literature representing information on the lymphocyte count in COVID-19 patients. 
Results: The results of our meta-analysis revealed that the number of lymphocytes retains a specific clinical and biological significance in this infection and lymphopenia is seemingly an important hematological abnormality that contributes to mirror the evolution toward an unfavorable outcome. 
Conclusion: The rapidly evolving nature of COVID-19 together with relentless disclosure of novel findings denotes a major limitation to the current study, and further investigations in the field of prognostic biomarkers will definitively pave the way to better manage patients with severe COVID-19. 
Keywords: SARS-CoV-2, COVID-19, Prognosis, Lymphocyte, Lymphopenia, Meta-analysis
Full-Text [PDF 1265 kb]   (366 Downloads)    
: Review Article | Subject: Infectious Diseases
Received: 2020/07/1 | Accepted: 2020/10/18 | Published: 2020/10/6
* Corresponding Author Address: Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Pourbagheri-Sigaroodi A, Bashash D, Olfatifar M, Salari S, Abolghasemi H. What We Know of the Prognostic Value of Lymphopenia in SARS-CoV-2 Infection. IJBC. 2020; 12 (3) :75-79
URL: http://ijbc.ir/article-1-1030-en.html

Volume 12, Issue 3 (September 2020 2020) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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