Volume 15, Issue 1 ( March 2023 2023)                   Iranian Journal of Blood and Cancer 2023, 15(1): 10-16 | Back to browse issues page

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Gholami A, Tasorian B, Vard A, Yousefi P, Tabibzadeh A. A case of Kikuchi–Fujimoto Disease in a SLE patient; potential importance of OR8U8 gene polymorphisms. Iranian Journal of Blood and Cancer 2023; 15 (1) :10-16
URL: http://ijbc.ir/article-1-1372-en.html
A case of Kikuchi–Fujimoto Disease in a SLE patient; potential importance of OR8U8 gene polymorphisms
Ali Gholami1 , Baharak Tasorian2 , Amir Vard3 , Parastoo Yousefi4 , Alireza Tabibzadeh * 5
1- School of Medicine, Arak University of Medical Sciences, Arak, Iran
2- Department of Rheumatology, Arak University Of Medical Sciences, Arak, Iran
3- Department of pathology, Arak University of Medical Sciences
4- Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5- Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , alireza.tabibzadeh@outlook.com
Abstract:   (674 Views)

Background: A Kikuchi–Fujimoto Disease (KFD) is a benign, self-limiting lymphadenopathy condition which mostly diagnosed by a pathologist due to a lymph node biopsy. In this study, we tried to report a case of KFD in a 38-year-old Iranian woman. Furthermore, an evaluation of some genetic polymorphisms in the patient’s peripheral blood was performed.
Case presentation: The patient was a 38-year-old female with a background of systemic lupus erythematosus, hypertension, hypothyroidism, and type 2 diabetes. The patient was under antibiotic treatment which was without any results. So she was referred to the rheumatology department for more evaluation. The patient went through various tests, Furthermore, the lymph node biopsy confirmed KFD. We could not find the EBV genome in the patient’s serum. The polymorphisms evaluation revealed wild-type alleles in all rs78460947 in OR8U8, rs34068039 in RIOX1, rs2799077 in ZSCAN26, and rs2273346 in MASP-2 but some other polymorphisms in OR8U8 gene. Patient treatment was performed by the lymph node excision during sampling and anti-inflammation.
Conclusion: KFD is a rare disease in Iranian patients. No specific Polymorphisms could be found in this study in KFD except in the OR8U8 gene. Further evaluation of these polymorphisms provides a diagnostic or prognostic tool for KFD by more comprehensive studies.

Keywords: Kikuchi–Fujimoto, Disease lymphadenopathy, Systemic lupus erythematosus
Full-Text [PDF 737 kb]   (403 Downloads)    
Subject: Pathology
Received: 2023/01/21 | Accepted: 2023/03/24 | Published: 2023/03/30
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