Contribution of Different Cell Signaling Pathways in Tumorigenesis

Gheybi, Elaheh; Hosseinzadeh, Pejman; Raoufinia, Ramin; Rostami, Mehdi; Mahmoudi, Ali; Soukhtanloo, Mohammad

Volume 18, Issue 2 (June-2026 2026) Iranian Journal of Blood and Cancer 2026, 18(2): 37-46 | Back to browse issues page

Mendeley

Zotero

RefWorks

Gheybi E, Hosseinzadeh P, Raoufinia R, Rostami M, Mahmoudi A, Soukhtanloo M. Contribution of Different Cell Signaling Pathways in Tumorigenesis. Iranian Journal of Blood and Cancer 2026; 18 (2) :37-46
URL: http://ijbc.ir/article-1-1899-en.html

Contribution of Different Cell Signaling Pathways in Tumorigenesis

Elaheh Gheybi¹

, Pejman Hosseinzadeh²

, Ramin Raoufinia³

, Mehdi Rostami⁴

, Ali Mahmoudi⁵

, Mohammad Soukhtanloo ^*⁶

1- Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. & Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. & Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran. & Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
4- Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
5- Department of Basic Medical Sciences, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran.
6- Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. & Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , soukhtanloom@mums.ac.ir

Abstract: (9 Views)

Cancer is a leading cause of death globally, and poses a major challenge to public health systems everyplace. The tumorigenesis is essentially initiated by the deregulation of fundamental intracellular signaling pathways which control important cell processes such as proliferation, survival and differentiation. Aberrations in these pathways have been shown for decades to underlie many of the hallmark capabilities of cancer cells such as unlimited replicative potential. Targeting oncogenic signaling has therefore become a major therapeutic strategy. We provide a review of five signaling networks that are often deregulated in cancer: PI3K/AKT/mTOR, NF-kappaB, Wnt/beta-catenin, Notch and Hippo/YAP-TAZ signaling and provide a unified analysis of this group of networks. We review here current knowledge of their individual and cooperative roles in tumor pathogenesis, and discuss implications for developing specific anticancer therapies.

Keywords: Cancer, Signaling pathways, Oncogenesis, PI3K/AKT/mTOR, NF-κB, Wnt/β-catenin, Notch, Hippo/YAP–TAZ

Full-Text [PDF 1848 kb] (7 Downloads)

: Review Article | Subject: Adults Hematology & Oncology
Received: 2026/05/13 | Accepted: 2026/06/1 | Published: 2026/06/30

Send email to the article author

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb