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IJBC 2008, 1(1): 33-38 Back to browse issues page
Minor Histocompatibility Antigen HA-1 Frequency and Acute GVHD in Some Hematopoietic Stem Sell Transplanted Iranian Patients
S Mohammadi * , M Shaiegan , KA Moghadam , GR Babaee , S Samiei , A Ghavamzadeh , F Shakerpour
Abstract:   (5787 Views)

Background: It is suggested that HA-1 mismatching among hematopoietic stem cell transplanted recipients-donors is associated with acute graft-versus-host disease (aGVHD). So the aim of this study was to evaluate HA-1 frequency and examine the correlation between HA-1 disparity and GVHD patients who received transplantation from a HLA-identical sibling.

Samples and Methods: the DNA was extracted from 30 pairs of HLA-A2-positive Iranian recipients-donors with GVHD I-IV and 25 pairs without GVHD. All the patients received HSCT from HLA-identical siblings. HA-1 was detected by SSP-PCR method. The HA-1 typing was performed using SSP method (SSP Minor Histocompatibility Antigen primer sets).

Results: The frequency of HA-1R and HA-1H alleles in patients were 0.55 and 0.45 respectively, and showed no significant difference with these alleles frequency in donors 0.53 and 0.47 respectively (p>0.05). The HA-1 disparity was detected in 8 out of 55 donor/recipient pairs (14.5%). The aGVHD (grades I-IV) occurred in 6 (75%) out of 8 patients but in spite of higher incidence of it in the group of patients with HA-1 incompatibility, it was not statistically significant.

Conclusion: In spite of higher frequency of HA-1 disparity in GVHD+ group our data did not reflect a significant association between the HA-1 disparity and risk of acute GVHD.

Keywords: HA-1 disparity, GVHD, Hematopoietic Stem cell transplantation (HSCT), Iranian
Full-Text [PDF 248 kb]   (1519 Downloads)    
: Research | Subject: Pediatric Hematology & Oncology
Received: 2011/01/26
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Mohammadi S, Shaiegan M, Moghadam K, Babaee G, Samiei S, Ghavamzadeh A et al . Minor Histocompatibility Antigen HA-1 Frequency and Acute GVHD in Some Hematopoietic Stem Sell Transplanted Iranian Patients. IJBC. 2008; 1 (1) :33-38
URL: http://ijbc.ir/article-1-32-en.html

Volume 1, Issue 1 (Autumn 2008) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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