[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره كنفرانس :: ثبت نام :: ارسال مقاله :: برقراري ارتباط :: راهنماي پايگاه ::
:: دوره 12، شماره 2 - ( 4-1399 ) ::
جلد 12 شماره 2 صفحات 54-57 برگشت به فهرست نسخه ها
Detection of FLT3 Gene Mutations In Patients With Acute Myeloid Leukemia In Surabaya, Indonesia: A Single-Center Study
چکیده:   (468 مشاهده)
Background:  FLT3 gene mutation contributes worse prognosis in patients with acute myeloid leukemia (AML). Almost 67% of patients with AML with FLT3 gene mutation cannot reach complete remission after induction therapy, and  they are also at high risk of  relapse. We aimed to investigate the FLT3-ITD, -TKD (D835) gene mutation prevalence in patients with AML at Surabaya and their association with leukocyte and bone marrow blast cell count.
Methods: 20 de novo patients with AML were recruited during February–July 2018. They were investigated through routine AML check-up and detection for FLT3-ITD, -TKD (D835) gene mutation. 
Results:  Four patients with de novo AML (20%) had FLT3-ITD gene mutation, and one  patient had  FLT3-TKD (D835) gene mutation. Median leukocyte count in patients with AML with FLT3-ITD mutation was higher than wild type patients ( 146.3×103/ µL vs 16.4 x 103 / µL, P=0,002). The mean bone marrow blast cell count was higher in patients with AML with FLT3-ITD mutation than wild type patients ( 86.5% vs 57.9%, P=0,047).  The difference in leukocyte and bone marrow blast cell count in patients with FLT3-TKD (D835) mutation could not be analyzed since there was only one patient with this mutation. 
Conclusion: The prevalence of FLT3-ITD gene mutation in patients in AML in Surabaya was 20% and FLT3-TKD (D835) was 5%. Patients with FLT3-ITD gene mutation was associated with leukocyte and bone marrow blast cell count. 
متن کامل [PDF 1159 kb]   (177 دریافت)    
: پژوهشي | موضوع مقاله: Adults Hematology & Oncology
دریافت: 1398/6/25 | پذیرش: 1399/2/31 | انتشار: 1399/5/23
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Notopuro P B, Jusak N, Harianto N. Detection of FLT3 Gene Mutations In Patients With Acute Myeloid Leukemia In Surabaya, Indonesia: A Single-Center Study. IJBC. 2020; 12 (2) :54-57
URL: http://ijbc.ir/article-1-935-fa.html

Detection of FLT3 Gene Mutations In Patients With Acute Myeloid Leukemia In Surabaya, Indonesia: A Single-Center Study. مجله خون و سرطان ايران. 1399; 12 (2) :54-57

URL: http://ijbc.ir/article-1-935-fa.html



دوره 12، شماره 2 - ( 4-1399 ) برگشت به فهرست نسخه ها
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
Persian site map - English site map - Created in 0.06 seconds with 30 queries by YEKTAWEB 4237