Showing 11 results for Bagheri
Seyed-Moayed Alavian, Hassan Abolghasemi, Seyyed Mohammad Miri, Maryam Keshvari, Pegah Karimi Elizee, Bita Behnava, Seyed-Vahid Tabatabaei, Bashir Hajibeigi, Kamran Bagheri Lankarani,
Volume 1, Issue 4 (Summer 2009)
Abstract
Background: Hepatitis C virus (HCV) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. In this study we aimed to evaluate the effects of pegylated interferon alfa-2a (PEG-IFN A-2a) in reducing serum ALT and eradicating serum hepatitis C virus (HCV) RNA in HCV infected polytransfused thalassemic patients.
Materials and Methods: A cohort of 51 HCV-RNA positive thalassemic patients were enrolled to our study and received 180 µg PEG-IFN A-2a once-weekly for 48 weeks. The primary end point was sustained virological response (SVR). The secondary outcome was normalization of ALT. Patient safety was assured by monthly, and if needed, weekly laboratory assessment and visits.
Results: Of 52 patients, 42 participants completed the treatment schedule. A sustained virological response (SVR) was attained in 22/51 (43%) cases. Among non-responders or relapsers to previous HCV antiviral therapy, 9/27 (33%) attained an SVR. Five patients died during treatment and 3 subjects discontinued the therapy because of adverse effects. Adverse events were generally mild, and laboratory abnormalities were rare.
Conclusion: A course of 48-week PEG-IFN A-2a monotherapy is effective in eradicating HCV-RNA during treatment. But about one third of thalassemic patients would relapse within 6 months of treatment schedule completion, in whom combination therapy is needed.
M Shaiegan, F Yari, H Abolghasemi, N Bagheri, M Paridar, A Heidari, Sh Kaskani, F Sabaghi, F Dikloo, M Zaman-Vaziri,
Volume 3, Issue 4 (Summer 2011)
Abstract
Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles
vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele
frequencies in different ethnic groups is useful for population genetic analyses.
Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry, HLA-A, B, DRB1 allele
frequencies were evaluated from 244 individuals who were recruited as unrelated volunteer donors by PCR-SSP
method in people of Fars ethnicity living in Tehran, Iran.
Results: The most frequent alleles found were HLA-A*02(19.8%), HLA-A*03(13%), HLA-A*11 and -24 (12.5%),
HLA-B*35(17.7%) HLA-B*51(13.2%), HLA-DRB1*11(20.8%), whereas HLA-A*34 and HLA-A*44 (0.2%), HLA-B*47,
B*54, B*56, B*73(0.2%), and HLA-DRB1*09 (0.4%) were the least frequent alleles.
Conclusion: Identifying HLA allele frequencies in different ethnic groups, helps in designing a better plan for
development of donor centers in different provinces of a country, and a more precise prediction of donor size in the
registry, in addition to finding suitable donors for patients in need of hematopoietic stem cell transplantation.
Keywords: HLA, unrelated donors, ethnic groups, Iran
Samaneh Bagheriyan, Fariba Borhani, Abbas Abbaszadeh,
Volume 5, Issue 1 (Autumn 2012)
Abstract
Background: Pain is described as the fifth vital sign, and inadequate pain management is linked to numerous
immediate and long-term negative outcomes. Venipuncture is one of the most painful medical procedures in children.
Distraction is one of the most effective ways to relieve pain. Reducing patients’ pain is important for all nurses
for many reasons. Unnecessary pain can damage the nurse-patient relationship, whereas knowledge of alternative
techniques can improve patient care and satisfaction.
Objective: The purpose of this quasi-experimental study was to test the analgesic effect of distraction during
venipuncture in children with thalassemia.
Materials and methods: Forty patients (6–12 years) who were suffering from major thalassemia and required
venipuncture were randomized into distraction group (n = 20, regular breathing exercise) and control group (n = 20,
without any intervention). The pediatric pain behavioral symptoms and numeric pain rating scale were used to assess
pain caused by venipuncture.
Results: The mean pain score based on the numerical scale was 5.60 ± 3.13 in the control group and 1.85 ± 1.42 in
the breathing exercise group (p=0.0001), and the mean score of behavioral pain symptoms was 3.80 ± 2.80 in the
control group and 0.96 ± 0.75 in the breathing exercise group (p=0.0001).
Conclusion: Distraction was demonstrated to be effective in reducing pain among children undergoing venipuncture.
This intervention requires minimum effort and time and is a convenient nursing intervention that might be used in
clinical settings.
Keywords: Pain, Thalassemia, Distraction, Children.
Samaneh Bagheriyan, Fariba Borhani, Abbas Abbaszade, Hadi Tehrani,
Volume 5, Issue 4 (Summer 2013)
Abstract
Background: The purpose of the present study was to assess the efficacy of non-pharmacological interventions on the anxiety among thalassemic children undergoing venipuncture.
Patients and Methods: This was a clinical trial on 60 thalassemic children aged 6-12 years undergoing venipuncture. Children were randomly divided into three groups: control, bubble making and regular breathing exercise. The anxiety level was assessed by anxiety self-reported scale before and after of catheter insertion. Kruskal-Wallis and Mann-Whitney U tests were used to compare the mean score of anxiety between groups.
Results: The mean anxiety score before venipuncture in control, bubble making, and regular breathing exercise groups was 31.7, 30.78, and 29 respectively. After venipuncture, the mean anxiety score was 41.50, 29.45 and 20.55, respectively. These findings indicated a significant difference in the mean anxiety scores between the three studied groups after the venipuncture. However, there was no significant difference between the mean anxiety score in the two distraction groups (bubble making and regular breathing exercise).
Conclusion: Needle-related procedural anxiety can be significantly reduced by using distraction. Bubble making and regular breathing exercise can be effective on the anxiety during venipuncture and might be considered for other minor invasive procedures in children. These non-pharmacological interventions require minimum effort and time and may be cost-effective and convenient nursing interventions that could be used easily in clinical settings.
Key words: Anxiety, distraction, thalassemia, venipuncture.
Morteza Bagheri, Isa Abdi Rad, Davood Maleki, Ali Eishi, Nasim Valizadeh,
Volume 10, Issue 2 ( June 2018 2018)
Abstract
Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is essential for diagnosis of CML by detection of various fusion transcripts such as b2a2 and b3a2 transcripts and Ph positive ALL by detection of e1a2 (p190) transcripts. We conducted this study to determine the frequency of various BCR-ABL fusion transcripts in the west Azerbaijani patients with CML.
Methods: RNA was isolated from peripheral blood samples by standard protocols. BCR-ABL fusion gene detection was carried out with one-step multiplex RT-PCR in 41 west Azerbaijani patients with CML.
Results: Among patients with CML, the frequencies of b2a2 and b3a2 transcripts were 52.5% and 12.5%, respectively. Co-expression of b3a2 and b2a2 transcripts was found in 12.5% of the patients.
Conclusion: The findings of this study showed that multiplex RT-PCR is a suitable technique to identify the typical BCR-ABL fusion transcripts in the west Azerbaijani patients with CML. Atypical transcripts possibly run away while using multiplex PCR.
Hoda Enayati, Hossein Ayatollahi, Mohammad Reza Keramati, Maryam Sheikhi, Hassan Bagheri, Seyyede Fatemeh Shams, Mohammad Hadi Sadeghian,
Volume 11, Issue 2 ( June 2019 2019)
Abstract
Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL.
Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as control group. Quantification of ROR1 mRNA expression by Real Time quantitative PCR was performed. The expressions of ROR gene in patients were compared with the control group.
Results: ROR1 mRNA expression (Fold Changes) in patients with ALL was 2.85±3.51. ROR1 mRNA expression in patients with ALL was significantly higher than normal individuals (P<0.001). There was not any relationship between the expression of ROR1 and cytogenetic abnormalities.
Conclusion: We assessed ROR1 gene expression on mRNA of 40 ALL patients at diagnosis. The results showed that ROR1 expression had significant increase in ALL patients compared with healthy controls.
Miss Atieh Pourbagheri-Sigaroodi, Davood Bashash, Meysam Olfatifar, Sina Salari, Hassan Abolghasemi,
Volume 12, Issue 3 ( September 2020 2020)
Abstract
Background: Although by comparing the number of deaths to the total number of cases one may conclude that most of the infected cases are recovering, taking a look at the increasing statistics of deaths shows that SARS-CoV-2 continues to take its toll. Since lymphocytes are the main immune cells battling with rapidly evolving viruses, it comes as no surprise to assume that a decreased number of these propitious soldiers may contribute to poor prognosis of the wide range of viral infections, including COVID-19.
Methods: To provide a better prospect representing the prognostic value of lymphopenia in COVID-19, we searched the national library of medicine Medline/PubMed and performed a meta-analysis of pertinent literature representing information on the lymphocyte count in COVID-19 patients.
Results: The results of our meta-analysis revealed that the number of lymphocytes retains a specific clinical and biological significance in this infection and lymphopenia is seemingly an important hematological abnormality that contributes to mirror the evolution toward an unfavorable outcome.
Conclusion: The rapidly evolving nature of COVID-19 together with relentless disclosure of novel findings denotes a major limitation to the current study, and further investigations in the field of prognostic biomarkers will definitively pave the way to better manage patients with severe COVID-19.
Miss Forouzan Bahmani, Miss Shima Azadpour, Miss Atieh Pourbagheri-Sigaroodi, Dr Davood Bashash,
Volume 14, Issue 3 ( September 2022 2022)
Abstract
The latest treatments have improved outcomes for patients with hematological malignancies, but relapse, treatment resistance and particularly side effects still remain as common limitations of these treatments. Given the disadvantages of the existing conventional therapeutic methods, developing more effective drugs with less toxicity and side effects is of paramount importance. Medicinal herbs have historically proven their worth as a pool of potential therapeutic agents for leukemia and lymphoma, and today they still represent a rich source for the recognition of new drug leads. The role of the positive synergistic effects of plant-derived natural products and common chemotherapeutic drugs is also considered as one of the rational reasons for paying attention to the medicinal plants in recent chemoprevention and chemotherapeutic investigations. Noteworthy, targeted delivery of plant-derived natural products via the incorporation of nanoparticles or antibodies would be a major step to improve their bioavailability and then to increase their therapeutic effects. In this study, we reviewed plant-derived agents approved and/or under investigation for hematological malignancies.
Dr Seyed H. Ghaffari, Dr Ebrahim Osfouri, Dr Mohammad Ahmadvand, Dr Davood Bashash, Dr Parisa Ghaffari, Dr Ahmadreza Niavarani, Dr Elham Hossaini, Dr Marjan Yaghmaie, Dr Roghieh Koohi, Dr Andisheh Ie Ghashgha, Dr Atieh Pourbagheri-Sigaroodi, Dr Seyed A. Mousavi, Dr Kamran Alimoghaddam, Dr Ardeshir Ghavamzadeh,
Volume 14, Issue 4 ( December 2022 2022)
Abstract
Background: Although Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML), not all patients reach complete remission and a considerable proportion of the patients develop resistance to Imatinib.
Material and Methods: In an attempt to increase the tail on the survival curve, we conducted a Phase I/II study of PR1/BCR-ABL multipeptides vaccination trial in CML patients with at least 15 months of Imatinib treatment and 5 months of persistent molecular residual disease.
Results: One month after the completion of the vaccinations, 4 patients nearly developed a 1-log fall in their BCR-ABL transcript level, with 4 patients achieving a major molecular response (MMR). Nine patients were followed for more than a period of 7 years. The vaccinations were associated with a MMR in five patients and a complete molecular response (CMR) in one patient. The removal of Imatinib in two patients who achieved MMR after the vaccinations led to a resurgence of the leukemia population and relapse.
Conclusion: Our study suggests that a combination of immunotherapy with Imatinib targeted therapy keeps the leukemia population under control, improving the long-lasting clinical and molecular response of CML patients, for at least 7 years.
Dr Najmaldin Saki, Dr Mohammadreza Javan, Dr Mohammad Shokouhian, Mrs Marzieh Bagheri, Miss Bahareh Moghimian-Boroujeni,
Volume 15, Issue 1 ( March 2023 2023)
Abstract
Background: Interaction between cancer cells and the coagulation system could have reciprocal effects on both groups. Coagulation-fibrinolytic cascade is a process that regulates the homeostasis of the body, and this process can be disrupted by several factors; one of the most important factor is cancer. In contrast, the coagulation-fibrinolytic system can also act as a factor in cancer growth and metastasis. Our aim in this study is to investigate this relationship.
Methods: The present study is based on Pubmed database information (2010- 2023) using the words “Cancer”, “Coagulation”, “Platelet “, “Tissue factor” and “ VTE “.
Results: Cancer cells disrupt the coagulation process by activating prooncogenic factors or inhibiting tumor suppressors, thereby inducing changes in platelets and coagulation factors, and increasing proteins involved in coagulation. These aberrations in the coagulation system result in coagulation abnormalities such as venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC). In various cancers, the activity of the coagulation and fibrinolytic systems increases, leading to an increase in coagulation and fibrinolysis factors. These factors are closely related to tumor size, tumor stage, cancer progression and metastasis.
Conclusions: The coagulation-fibrinolytic system is closely related to cancers.Cancer cells can disrupt the coagulation-fibrinolysis process. Also, coagulation-fibrinolytic agents can both lead to cancer progression and can be used as a marker for the prognosis of some cancers.
Mahda Delshad, Mohammad Amin Omrani, Atieh Pourbagheri-Sigaroodi, Davood Bashash,
Volume 15, Issue 3 ( Special Issue (AI in Medicine) - August 2023 2023)
Abstract
The field of cancer research has been profoundly impacted by the utilization of artificial intelligence (AI), particularly through the analysis of medical records encompassing genomics, transcriptomics, proteomics, and imaging data. Subdomains of AI, such as machine learning (ML) and deep learning (DL), possess the capability to analyze intricate patterns within these records. This allows for groundbreaking advancements in cancer diagnosis, prognosis, and treatment by extracting valuable insights from sources such as histology and radiology imaging. The integration of AI-based models has led to improved prediction, diagnosis, and even treatment of various types of cancer, resulting in enhanced performance within the field of oncology. However, AI also faces challenges including ethical and legal considerations, data quality and accessibility, and issues pertaining to model interpretability. It is crucial to develop and evaluate AI-based systems in collaboration with clinicians and researchers to ensure their safety, reliability, and validity in cancer research.