Showing 5 results for Risk Factors
Noorwati Sutandyo, Demak Tobing, Kardinah Kardinah,
Volume 10, Issue 4 (12-2018)
Abstract
Background: Venous thromboembolism (VTE) is a significant complication in cancer patients which was found in 4-20% of the patients. This study was aimed to evaluate risk factors of deep vein thrombosis (DVT) in cancer patients in an oncology center in Indonesia.
Methods: This was a retrospective cohort study. Data were obtained from medical records of adult cancer patients with DVT referring to Dharmais National Cancer Center in Indonesia since 2013-2016. Control group were adult cancer patients without DVT. Association of risk factors (sex, age, presence of metastasis, Khorana score, complete blood count and D-dimer level) with DVT were compared and analyzed between DVT patients and control group. Results: A total of 129 cancer patients with DVT at Dharmais Cancer Hospital during year 2013-2016 met the inclusion criteria. Median age of the patients was 56 years old. Multivariate logistic regression analysis was performed to investigate the effect of sex, age, hypertension, diabetes, chemotherapeutic agents, hemoglobin level, leukocyte counts and D-dimer level to the occurrence of DVT in cancer patients. Hypertension (OR 16.7, P<0.001), chemotherapy (OR 5.0, P=0.012), D-dimer level (OR 1.00, P=0.030) and leukocyte counts (OR 1.00, P=0.017) were significant risk factors to have contribution to the occurrence of DVT in cancer patients.
Conclusion: Hypertension, history of chemotherapy, leukocytosis, and D-dimer level were significant risk factors for DVT in cancer patients.
Mina Danaei, Aliakbar Haghdoost, Mohsen Momeni,
Volume 11, Issue 3 (9-2019)
Abstract
Cancer is a critical health threat in the world. It has an ongoing increasing trend.The aim of this study was to describe the trend, most common types of cancer and the gender ratio of cancer in Iran and its provinces. We searched PubMed, Google Scholar, Scopus, and Science directs from 2000 to 2017 using Keywords including “Cancer”, “Neoplasms”, “Malignancy”, “Tumor”, “Incidence”, “Epidemiology”, and “Iran”.The most common cancers of Iranian men were skin, stomach, bladder, prostate and colorectal cancers, respectively. The most common cancers of Iranian women were breast, skin, colorectal, stomach, and esophagus cancers, respectively. Cancer has an increasing trend in Iran. Cancer has more burden in the Northern and Northwest provinces of Iran. There was a notable diversity between the occurrences of different types of cancer between different provinces of Iran. Men were more predisposed to cancer. Iran experienced an increasing trend of cancer, like other countries. Different provinces of Iran experienced different patterns. The quality of cancer registry was different, also in many provinces, there were no strong epidemiological studies about cancer. The prevalence of some risk factors was differed in provinces.
Mina Danaei, Zahra Hoseini, Mohsen Momeni,
Volume 13, Issue 3 (9-2021)
Abstract
Background: Breast cancer is an important preventable health problem, worldwide. In this study, the frequency of breast cancer risk factors and the level of individuals risk using different risk assessment instruments were assessed.
Methods: This cross-sectional study was conducted in Kerman, Iran, 2018. Seven hundred women referred to the comprehensive health care centers were participated in the study using a cluster sampling method. The International Breast Cancer Intervention Study (IBIS) and Breast Cancer Screening (BCS) risk assessment models were used. The frequency of different breast cancer risk factors was asked using the self-administered questionnaire. Data were entered into the SPSS software. The descriptive analysis and Pearson correlation test were used.
Results: The frequency of being overweight/obesity, having a sedentary lifestyle, second-hand exposure to tobacco, and having anxiety was 54.1%, 54.7%, 21.3%, 26%, respectively. Considering the lifetime risk ≥20% according to the IBIS and BCS models, 2.8% and 0.1% of participants were high risks. There was a significant positive correlation between the IBIS 5-year risk of breast cancer and the BCS chart risk (r=0.716, P≤0.001). There was not any significant correlation between the IBIS lifetime risk of breast cancer and the BCS chart risk (r=0.035, P=0.358).
Conclusion: The prevalence of modifiable risk factors of breast cancer is considerable in Iranian women. Community-based, primordial and primary prevention intervention should design. There are some national and international breast cancer risk assessment models, but their accuracy in the Iranian population and the perfect threshold score to determine high-risk individuals is not clear.
Vajihe Rouhi, Yunes Jahani, Reza Malekpour Afshar, Hossein Mirshekarpour, Armita Shahesmaeili,
Volume 13, Issue 3 (9-2021)
Abstract
Background: This study aimed to estimate the incidence of thyroid cancer and completeness of thyroid cancer case registration in Kerman province, Iran using three source capture-recapture approach during years 2008-2015.
Methods: All new cases of thyroid cancers reported during 2008-2015 which were registered by pathology, nuclear medicine and medical records were included in this study. Using the personal identifiers, common cases between sources were linked. The log-linear Poisson regression analysis was applied to estimate the number of unregistered cases. The incidence rate per 100,000 population was calculated. To study the trend, Joint-point regression analysis was performed.
Results: Overall, 1153 new cases of thyroid cancer were reported by three sources. Most cases were female (81/7%). The mean age at diagnosis was 41.53±15.69 years. The estimated number of thyroid cancer cases was 1323. The estimated incidence per 100,000 population varied from 4.5 in 2011 to 11 in 2015. The female to male ratio varied from 3.1 in 2015 to 6.7 in 2011. The completeness of registration for all three sources varied from 33.7% in 2008 to 95.1% in 2013. The completeness of medical records, pathology reports, and nuclear medicine reports were 33.1%, 50.7%, and 66.2%, respectively.
Conclusion: Despite some improvements in completeness of thyroid cancer registration during the study period, there are still fluctuations within the study period. Furthermore, considering each source separately, the completeness of registration is not satisfactory. Therefore, more effort should be done to increase the completeness of thyroid cancer registration specially through the pathology source.
Naseem Fatima, Syed Tasleem Raza, Vijay Kumar,
Volume 18, Issue 1 (3-2026)
Abstract
Gallbladder cancer (GBC) is an infrequent type of malignant neoplasm and ranks fifth among gastrointestinal malignancies in the world. However, GBC is prevalent in India, and population-based cancer registries’ (PBCRs) data revealed its higher incidence rate in North India. Due to the fact that the etiology of this cancer is quite complex, the majority of the cases are diagnosed at a very advanced stage owing to a lack of clinical appearance, which is non-specific. The majority of the cases come to light by coincidence at the time of histopathological examination of cholecystectomy. Several risk factors have been reported that may play an important role in the development and progression of GBC. There is a strong association between gallbladder inflammatory diseases (GIDs), including cholelithiasis (gallstones) and GBC. The presence of gallstones increases the risk of GBC more than threefold and appears to be stronger among ethnic groups that have higher rates of GBC. Surgery is the primary treatment that can cure early-stage gallbladder cancer. Apart from surgery, the use of immunotherapy, molecularly targeted medications, and new developments in radiation and chemotherapy (neoadjuvant-adjuvant gemcitabine, cisplatin, and capecitabine) has made gallbladder cancer treatment more promising in recent years, but there is still insufficient evidence to support their ability to improve patient outcomes, so more research is needed to address these issues; therefore, customized care needs to be used.
