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Elevation of D-Dimer, But Not PT and aPTT, Reflects the Progression of COVID-19 Toward an Unfavorable Outcome: A Meta-Analysis
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| Davood Bashash *, Hassan Abolghasemi, Sina Salari, Meysam Olfatifar, Peyman Eshghi, Mohammad Esmaeil Akbari Prof. |
| Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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Abstract: (377 Views) |
Background: Coronavirus disease 2019 (abbreviated as COVID-19) is a mysterious respiratory syndrome symptomatically spanning from healthy carriers to patients with life-threatening complications, in some cases, leading to a mournful death. For the time being, the contributory role of hematologists is much more recognized in the management of COVID-19, since the emergence of coagulopathy has recently been the focus of many studies in SARS-CoV-2 infection.
Methods: To provide a well-conceptualized viewpoint demonstrating the prognostic value of coagulation-related laboratory tests, we planned to perform a meta-analysis of pertinent literature representing information on PT, aPTT, and D-dimer tests in patients with COVID-19.
Results: Albeit the estimated pooled means of PT and aPTT were higher in severe cases, their mean values were not significantly higher as compared with patients in a non-severe condition. On the other hand, the mean value of D-dimer in severe patients was significantly higher than non-severe cases (X2=6.34, P=0.01), highlighting that the elevation of this parameter may be associated with the progression of the disease toward an unfavorable clinical outcome.
Conclusion: Even though at the time of writing this article the lack of adequate and appropriate studies denotes a major limitation to the current study, planning for the future research to determine the prognostic value of laboratory tests reflecting SARS-CoV-2-induced coagulopathy, mainly D-dimer, will definitively cast a flash of light on the significance of therapeutic anticoagulation at least for those with no absolute contraindication. |
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| Keywords: SARS-CoV-2, COVID-19, Prognosis, Coagulation, D-dimer, PT, PTT, Meta-analysis |
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Full-Text [PDF 2514 kb]
(98 Downloads)
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: Review Article |
Subject:
Infectious Diseases
Received: 2020/05/10 | Accepted: 2020/06/8 | Published: 2020/08/13
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| * Corresponding Author Address: Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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