Antibiotic-Induced Obesity in Childhood Acute Lymphoblastic Leukemia: An Intricate Network of Antibiotic-Microbiome-Obesity

Bandar, Bita; Mohebbi, Alireza; Saki, Najmaldin; Yousefi-Avarvand, Arshid

doi:10.61186/ijbc.16.1.35

Volume 16, Issue 1 (March 2024 2024) Iranian Journal of Blood and Cancer 2024, 16(1): 35-42 | Back to browse issues page

‎ 10.61186/ijbc.16.1.35

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Bandar B, Mohebbi A, Saki N, Yousefi-Avarvand A. Antibiotic-Induced Obesity in Childhood Acute Lymphoblastic Leukemia: An Intricate Network of Antibiotic-Microbiome-Obesity. Iranian Journal of Blood and Cancer 2024; 16 (1) :35-42
URL: http://ijbc.ir/article-1-1480-en.html

Antibiotic-Induced Obesity in Childhood Acute Lymphoblastic Leukemia: An Intricate Network of Antibiotic-Microbiome-Obesity

Bita Bandar¹

, Alireza Mohebbi²

, Najmaldin Saki¹

, Arshid Yousefi-Avarvand ^*³

1- Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , Arshid.yousefi5@gmail.com

Abstract: (902 Views)

Acute Lymphoblastic Leukemia (ALL) is the most prevalent cancer among children, necessitating an investigation of its associated complications and comorbidities. Of particular concern is the frequent occurrence of obesity in patients undergoing treatment for childhood leukemia. Obesity is recognized as a risk factor for various cardiovascular conditions, venous thromboembolism (VTE), hypertension, hyperglycemia, diabetes mellitus and non-insulin-dependent diabetes mellitus (NIDDM). Consequently, a comprehensive examination of this issue from multiple perspectives is essential. The disturbance in gut microbiota diversity, resulting from the administration of Chemotherapy drugs and Antibiotics to these patients, may contribute to the development of obesity. Given the heightened risk of obesity in children with ALL, it is imperative to explore the relationship between obesity and factors such as antibiotic usage in this population. This review aims to synthesize and analyze the most recent published evidence concerning the association of obesity and antibiotics in pediatric ALL. Through this comprehensive analysis, we seek to shed light on the intricate interplay between antibiotics, obesity, and childhood ALL, with the ultimate goal of guiding future research and clinical interventions.

Keywords: Childhood Acute Lymphoblastic Leukemia, Pediatric, Obesity, Antibiotics, Chemotherapy

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: Special Issue | Subject: Pediatric Hematology & Oncology
Received: 2023/11/6 | Accepted: 2023/12/26 | Published: 2024/03/25

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