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Volume 17, Issue 1 (March-2025 2025)
Iranian Journal of Blood and Cancer 2025, 17(1): 40-46 |
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Salimi B, Mabani M, Seifi S, Rostami P, Dehghanifard A, Khosravi N, et al . EGFR Mutations, ROS1, and ALK Rearrangements in Iranian Non-Small Cell Lung Cancer Patients. Iranian Journal of Blood and Cancer 2025; 17 (1) :40-46
URL: http://ijbc.ir/article-1-1683-en.html
URL: http://ijbc.ir/article-1-1683-en.html
Babak Salimi1 
, Maryam Mabani1 , Sharareh Seifi1 , Parsa Rostami1 , Ali Dehghanifard2 , Negin Khosravi3 , Marziye Madadkar Borna4 , Elaheh Sadat Jamali5 , Sarah Shiari1 , Hanieh Sattari1 , Adnan Khosravi *6
, Maryam Mabani1 , Sharareh Seifi1 , Parsa Rostami1 , Ali Dehghanifard2 , Negin Khosravi3 , Marziye Madadkar Borna4 , Elaheh Sadat Jamali5 , Sarah Shiari1 , Hanieh Sattari1 , Adnan Khosravi *6
1- Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
3- Department of Genetic, Ahar Branch, Islamic Azad University, Ahar, Iran.
4- Department of Biology, East Tehran Islamic azad university,Tehran, Iran.
5- Immunology Department, Pasteur Institue of Iran, Tehran, Iran.
6- Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,adkhosravi@yahoo.com
2- Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
3- Department of Genetic, Ahar Branch, Islamic Azad University, Ahar, Iran.
4- Department of Biology, East Tehran Islamic azad university,Tehran, Iran.
5- Immunology Department, Pasteur Institue of Iran, Tehran, Iran.
6- Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,
Abstract: (176 Views)
Background: Driver mutations, particularly in the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and ROS1 genes, are prevalent in non-small cell lung cancer (NSCLC) and significantly influence patient outcomes. These mutations have become crucial biomarkers for targeted therapy, guiding treatment decisions and improving patient survival. Our study aims to evaluate the prevalence of EGFR mutations, ALK, and ROS1 gene rearrangements in a cohort of Iranian NSCLC patients and to investigate their association with patient characteristics.
Materials and Methods: Tissue samples from patients diagnosed with non-small cell lung cancer (NSCLC) were subjected to molecular analysis. EGFR mutations, ALK, and ROS1 gene rearrangements were assessed. Additionally, the correlation between these genetic alterations and patient demographics, including age and gender, was explored.
Results: Driver mutations or rearrangements were detected in approximately one-third of NSCLC cases. EGFR mutations were the most common, occurring in 22.44% of patients. ALK and ROS1 rearrangements were identified in 8.18% and 2.11% of patients, respectively. The EGFR mutation frequency in patients younger than 36 years was 16%. In contrast, the mutation frequency in older patient cohorts ranged from 11% to 15%. Among EGFR mutations, exon 19 deletions (13.35%) and L858R point mutations (6.81%) were the most prevalent. Notably, exon 19 deletions were more frequent in female patients (27.92%) compared to male patients (9.90%).
Conclusion: EGFR mutations were more prevalent than ALK and ROS1 rearrangements in our cohort. Exon 19 deletions and L858R point mutations were the most common EGFR mutations, with a higher frequency observed in female patients. These mutations are frequently associated with lung adenocarcinoma.
Results: Driver mutations or rearrangements were detected in approximately one-third of NSCLC cases. EGFR mutations were the most common, occurring in 22.44% of patients. ALK and ROS1 rearrangements were identified in 8.18% and 2.11% of patients, respectively. The EGFR mutation frequency in patients younger than 36 years was 16%. In contrast, the mutation frequency in older patient cohorts ranged from 11% to 15%. Among EGFR mutations, exon 19 deletions (13.35%) and L858R point mutations (6.81%) were the most prevalent. Notably, exon 19 deletions were more frequent in female patients (27.92%) compared to male patients (9.90%).
Conclusion: EGFR mutations were more prevalent than ALK and ROS1 rearrangements in our cohort. Exon 19 deletions and L858R point mutations were the most common EGFR mutations, with a higher frequency observed in female patients. These mutations are frequently associated with lung adenocarcinoma.
: Original Article |
Subject:
Adults Hematology & Oncology
Received: 2025/01/3 | Accepted: 2025/03/6 | Published: 2025/03/30
Received: 2025/01/3 | Accepted: 2025/03/6 | Published: 2025/03/30
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