Natural killer cell-based Immunotherapy for Solid tumors: A Comprehensive Review

Singh, Vinod Kumar; Awasthi, Seema; Sharma, Sonika

Volume 17, Issue 2 (June-2025 2025) Iranian Journal of Blood and Cancer 2025, 17(2): 83-98 | Back to browse issues page

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Singh V K, Awasthi S, Sharma S. Natural killer cell-based Immunotherapy for Solid tumors: A Comprehensive Review. Iranian Journal of Blood and Cancer 2025; 17 (2) :83-98
URL: http://ijbc.ir/article-1-1752-en.html

Natural killer cell-based Immunotherapy for Solid tumors: A Comprehensive Review

Vinod Kumar Singh ^*¹

, Seema Awasthi²

, Sonika Sharma²

1- TMMC&RC, Teerthanker Mahaveer University, Moradabad, UP, India. , drvinodkumarsingh85@gmail.com
2- TMMC&RC, Teerthanker Mahaveer University, Moradabad, UP, India.

Abstract: (166 Views)

Natural Killer Celle (NK) are innate immune cells with potent cytotoxic activity against tumor cells, making them attractive candidates for cancer immunotherapy. While NK cell-based therapies have shown promise in hematologic malignancies, their efficacy against solid tumors remains challenging due to the immunosuppressive tumor microenvironment (TME) and limited NK cell persistence. This review discusses recent advances in NK cell-based immunotherapies, including adoptive NK cell transfer, NK cell engagers, and genetic modifications to enhance their anti-tumor activity. We also explore the barriers to effective NK cell therapies in solid tumors and potential strategies to overcome these limitations.

Keywords: Natural Killer (NK) Cells, Adoptive NK Cell Transfer, Tumor Microenvironment, Immunosuppressive Factors

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: Review Article | Subject: Adults Hematology & Oncology
Received: 2025/05/15 | Accepted: 2025/06/28 | Published: 2025/06/30

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