[Home ] [Archive]    
:: Home :: About Journal :: Registration :: Article Submission :: Contact us :: Site Map ::
:: Volume 1, Issue 2 (Winter 2009) ::
IJBC 2009, 1(2): 79-81 Back to browse issues page
Breast Cancer Associated with Dermatomyositis
Nasim Valizadeh *
Abstract:   (10697 Views)
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy with characteristic skin lesions. Case series have shown an association between dermatomyositis and malignancy. Malignancy has been found in 15-25% of the adult patients with dermatomyositis. A 50-year-old new case of breast cancer, was admitted with muscle weakness and inability to walk. Physical examination revealed fever, periorbital edema, a heliotrope rash on the upper eyelids, a large right-sided breast mass and erythematous plaques on the upper chest, abdomen and legs. During hospitalization, she developed a nasal speech, dysphasia, and nasal regurgitation of food and water. A clinical diagnosis of dermatomyositis secondary to breast adenocarcinoma was made according to the skin lesions, muscle weakness, elevated ESR, and increased CPK and LDH levels. Wide spectrum antibiotics and Dexamethasone were administered but fever persisted. Although chemotherapy was recommended, she developed respiratory failure and aspiration pneumonia and died. Dermatomyositis is one of the paraneoplastic syndromes which are associated with breast cancer. Although treatment of dermatomyositis generally includes corticosteroids with or without immunosuppressants, cancerdirected specific therapy including surgery and/or chemotherapy would be more effective. Dermatomyositis should be considered in breast cancer patients with skin lesions and muscle weakness and cancer-specific therapy should be started as soon as possible.
Keywords: dermatomyositis, breast neoplasm, drug therapy, exanthema
Full-Text [PDF 127 kb]   (2700 Downloads)    
: Research | Subject: Pediatric Hematology & Oncology
Received: 2011/01/26
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Valizadeh N. Breast Cancer Associated with Dermatomyositis. IJBC. 2009; 1 (2) :79-81
URL: http://ijbc.ir/article-1-24-en.html

Volume 1, Issue 2 (Winter 2009) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3877