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IJBC 2012, 4(4): 169-178 Back to browse issues page
Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
Akram Safaei *, F Zaker
Abstract:   (6714 Views)
Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizing enzymes (CYP family, NQO1, GST), enzymes involved in folate metabolism (MTHFR, MTRR, SHMT, TS), and DNA repair enzymes (RAD51, XRCC1, ERCC2), chromosome translocation and epigenetic events discussed in this review, can be introduced as candidate alterations in acute lymphoblastic leukemia. Keyword: Acute lymphoblastic leukemia, genetic predisposition to disease, DNA repair enzymes, translocation, review.
Keywords: Keyword: Acute lymphoblastic leukemia, genetic predisposition to disease, DNA repair enzymes, translocation, review.
Full-Text [PDF 555 kb]   (1643 Downloads)    
: Research | Subject: Pediatric Hematology & Oncology
Received: 2012/01/8 | Accepted: 2012/04/9 | Published: 2013/03/14
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Safaei A, Zaker F. Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia. IJBC. 2012; 4 (4) :169-178
URL: http://ijbc.ir/article-1-386-en.html


Volume 4, Issue 4 (Summer 2012) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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