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:: Volume 9, Issue 2 (June 2017) ::
IJBC 2017, 9(2): 44-47 Back to browse issues page
The Difference in Initial Leukocyte Count, Bone Marrow Blast Cell Count and CD 34 Expression in Patients with Acute Myeloid Leukemia with and without NPM1 gene Mutation
Paulus Notopuro *, Harianto Notopuro , Imam Budiwijono , Purwanto AdiPireno
MD Faculty of Medicine Airlangga University
Abstract:   (427 Views)

Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients with AML with and without NPM1 mutation.
Methods: In this study, 25 de novo patients with AML were investigated for NPM1 exon 12 gene mutation using ASO-RT-PCR. Initial leukocyte counts, bone marrow blast cell counts and expression of CD34 on blasts were examined in all patients.
Results: 13 of 25 de novo patients with AML (52%) had NPM1 gene mutation. Initial leukocyte counts in AML patients with NPM1 gene mutation was not significantly higher than patients without this mutation (23.400 /µL versus 16.000 /µL, P=0.53). Blast cell counts were not significantly higher in AML patients with NPM1 gene mutation than patients without mutation. (41% versus 19%, P=0,18). Expression of CD34 was not significantly different between AML patients with and without NPM1 gene mutation (P=0.48).
Conclusion: There were no difference in initial leukocyte count, blast cell count and CD34 expression among patients with AML with and without NPM1 exon 12 type A gene mutation.

Keywords: Acute myeloid leukemia, Initial leukocyte count, Bone marrow blast cell count, CD34 expression, NPM1 gene mutation
Full-Text [PDF 887 kb]   (365 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Received: 2017/02/8 | Accepted: 2017/05/14 | Published: 2017/06/28
* Corresponding Author Address: Surabaya
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Notopuro P, Notopuro H, Budiwijono I, AdiPireno P. The Difference in Initial Leukocyte Count, Bone Marrow Blast Cell Count and CD 34 Expression in Patients with Acute Myeloid Leukemia with and without NPM1 gene Mutation. IJBC. 2017; 9 (2) :44-47
URL: http://ijbc.ir/article-1-709-en.html
Volume 9, Issue 2 (June 2017) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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