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:: Volume 10, Issue 3 (September 2018 2018) ::
IJBC 2018, 10(3): 92-95 Back to browse issues page
Adrenocortical Carcinoma Mimicking Pheochromocytoma: A case Report and Review of Literature
Mazaher Ramezani , Mahdokht Azizi , Masoud Sadeghi *
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (175 Views)
Adrenocortical carcinoma (ACC) is an uncommon malignancy originating from cortex of adrenal gland. The most common pitfall in diagnosis of ACC is to distinguish it from pheochromocytoma. Here we report a 62-year-old hypertensive man with presentation of dyspnea. The laboratory data showed an increase in urine cortisol and renin with a mild increase in aldosterone, but decrease in adrenocorticotropic hormone. Computerized tomography (CT) scanning revealed heterogeneous mass with enhancement in the adrenal region. The patient underwent surgery with an empirical diagnosis of pheochromocytoma, whereas ACC with high mitotic rate of about 50 mitoses/50 high-power field with vascular invasion was reported on histopathology. Immunohistochemistry was positive for Vimentin, Inhibin-α, Melan-A, and Synaptophysin. Ki-67 was positive in 25% of tumor cells. The results confirmed the diagnosis. ACC should be considered in differential diagnosis of adrenal masses especially in cases of hypertension and Cushing syndrome.
Keywords: Adrenocortical carcinoma, Pheochromocytoma, Hypertension, Adrenal gland tumors, Immunohistochemistry
Full-Text [PDF 2448 kb]   (198 Downloads)    
: case report | Subject: Pathology
Received: 2018/04/14 | Accepted: 2018/09/29 | Published: 2018/10/24
* Corresponding Author Address: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
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Ramezani M, Azizi M, Sadeghi M. Adrenocortical Carcinoma Mimicking Pheochromocytoma: A case Report and Review of Literature. IJBC. 2018; 10 (3) :92-95
URL: http://ijbc.ir/article-1-798-en.html


Volume 10, Issue 3 (September 2018 2018) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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