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:: Volume 10, Issue 4 (December 2018 2018) ::
IJBC 2018, 10(4): 114-116 Back to browse issues page
Methylation Status of SMG1 Gene Promoter in Multiple Myeloma
Hamid Gholipour, Saeid Abroun, Mehrdad Noruzinia, Sasan Ghaffari, Amirhosein Maali, Mehdi Azad *
Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract:   (657 Views)
Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma.
Methods: Methylation status of SMG1 promoter in 9 patients with multiple myeloma and 4 healthy subjects as control was determined by Methylation-specific PCR (MSP) method.
Results: SMG1 promoter in all myeloma patients was hemi-methylated. Meanwhile, in healthy subjects, two cases were hemi-methylated and the other two were normal.
Conclusion: The results of this study indicated that the prevalence of SMG1 promoter methylation in patients with multiple myeloma was higher than general population which could be important in understanding the pathogenesis of the disease.
Keywords: Multiple Myeloma, DNA methylation, SMG1 gene
Full-Text [PDF 635 kb]   (311 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Received: 2018/09/7 | Accepted: 2018/11/10 | Published: 2019/01/5
* Corresponding Author Address: Qazvin
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Gholipour H, Abroun S, Noruzinia M, Ghaffari S, Maali A, Azad M. Methylation Status of SMG1 Gene Promoter in Multiple Myeloma . IJBC. 2018; 10 (4) :114-116
URL: http://ijbc.ir/article-1-826-en.html


Volume 10, Issue 4 (December 2018 2018) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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