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:: Volume 11, Issue 3 (September 2019 2019) ::
IJBC 2019, 11(3): 96-100 Back to browse issues page
TPMT and ITPA Gene Polymorphism and Their Adverse Events during Chemotherapy of Acute Lymphoblastic Leukemia among Bangladeshi Children
Sanjana Zaman, Hiroko Fukushima, Ryoko Suzuki, Shoji Yoshimatsu, Mohammad Delwer Hossain Hawlader *, Takashi Fukushima
North South University
Abstract:   (4255 Views)
Background: The pharmacogenetic-oriented approach reduces the toxicity and increases the safety of chemotherapeutic agents. 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) contribute to variable responses and adverse effects among leukemia patients treated with 6-MP. The aim of our study was to identify the prevalence of TPMT and ITPA gene polymorphisms among Bangladeshi children with acute lymphoblastic leukemia (ALL) and their association with the adverse effects of 6-MP during the treatment.
Methods: We recruited 75 patients with ALL and 75 volunteers with minor illnesses as the control group. Genotyping for TPMT (TPMT*3C, *3B, *2) and ITPA (ITPAc.94C>.A) was performed. The relationship between genotypes and adverse effects of 6-MP was investigated.
Results: The frequency of TPMT*3B, TPMT*3C and ITPA polymorphisms among volunteers was 0.006, 0.020, and 0.093, respectively, whereas TPMT*3C and ITPA polymorphisms among ALL patients was 0.010 and 0.153, respectively. ALL patients with the ITPA variant developed fever (OR=6.9, 95% CI=1.99-23.91), neutropenia (OR=7.68, 95% CI=2.21-26.61), hyperbilirubinemia (OR=4.73, 95% CI=1.39-16.07) and raised serum ALT (OR=4.73, 95% CI=1.52-14.68) which were significant in comparison with those without polymorphism.
Conclusion: The frequency of ITPAc.94C>A among Bangladeshi children was high. Adverse effects of chemotherapy in patients with ALL suggests the importance of ITPA genotyping in ALL patients prior to starting chemotherapy.
Keywords: TPMT gene polymorphisms, ITPA enzyme, Polymorphism, Acute lymphoblastic leukemia, Children, 6-mercaptopurine toxicity
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: Research | Subject: Pediatric Hematology & Oncology
Received: 2019/03/3 | Accepted: 2019/08/29 | Published: 2019/10/8
* Corresponding Author Address: 4. Department of Public Health, School of Health and Life Sciences, North South University, Dhaka, Bangladesh
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Zaman S, Fukushima H, Suzuki R, Yoshimatsu S, Hawlader M D H, Fukushima T. TPMT and ITPA Gene Polymorphism and Their Adverse Events during Chemotherapy of Acute Lymphoblastic Leukemia among Bangladeshi Children. IJBC 2019; 11 (3) :96-100
URL: http://ijbc.ir/article-1-883-en.html

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Volume 11, Issue 3 (September 2019 2019) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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