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:: Volume 12, Issue 1 (March 2020 2020) ::
IJBC 2020, 12(1): 6-11 Back to browse issues page
Expression of Proviral Integration of Moloney Virus-2 (PIM2) Gene in Patients with Acute Myeloid Leukemia and its Clinical Significance
Dina El Dahshan *, Amira Hammam, Aya Ahmed, Mohamed El Samra
Clinical Pathology Department, Faculty of Medicine, Beni-Suef University
Abstract:   (263 Views)
ackground: Despite extensive research in leukemia, intracellular events leading to prolongation of cell cycle and resistance to pro-apoptotic factors are still not clearly defined. In recent years, the search for such events led to focusing on an anti-apoptotic factor, PIM-2 (Proviral integration of Moloney virus-2). The aim of the present study was to assess the expression of PIM2 gene in patients with acute myeloid leukemia (AML) through quantitative real time polymerase chain reaction (QRT-PCR) and to correlate the results with clinical and laboratory findings of the patients as well as their response to the treatment. Methods: 80 patients with AML and control group were enrolled in the present study. QRT-PCR was used to study PIM2 gene expression.
Results: The mean expression level of PIM2 gene was significantly higher in AML patients (3.5941±7.7736) compared with the control group (0.5303±0.4014) (P=0.034). Its expression level was not different in terms of achieving remission. A positive correlation was observed between PIM2 gene expression and total leucocytic count (R=0.059, P=0.719), while there was a negative correlation between the gene expression and platelet count (R=-0.118, P=0.470). No significant correlation was found between PIM2 gene and patients’ response to treatment as (P=0.883) although it’s level was higher in patients who did not achieve complete remission (6.1±11.9) than patients who achieved complete remission (3.1±5.3).
Conclusion: The present study showed higher PIM2 expression level in AML patients than normal population. Also, its level was higher in patients who did not achieve complete remission.
Keywords: Acute myeloid leukemia PIM2 gene expression QRT-PCR, Clinical association Survival, Outcome
Full-Text [PDF 470 kb]   (62 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Received: 2019/06/20 | Accepted: 2020/02/29 | Published: 2020/05/2
* Corresponding Author Address: Sheikh zayed 6 october
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El Dahshan D, Hammam A, Ahmed A, El Samra M. Expression of Proviral Integration of Moloney Virus-2 (PIM2) Gene in Patients with Acute Myeloid Leukemia and its Clinical Significance. IJBC. 2020; 12 (1) :6-11
URL: http://ijbc.ir/article-1-909-en.html


Volume 12, Issue 1 (March 2020 2020) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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