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Volume 12, Issue 1 ( March 2020 2020)
Iranian Journal of Blood and Cancer 2020, 12(1): 24-28 |
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Dideban A, Seyedrezazadeh E, Sharifi A, Abd-Nikfarjam B, Sadeghi M. Association of MicroRNA-146a rs2910164 Polymorphism and Lung Cancer in Iranian Population: A Case-Control Study. Iranian Journal of Blood and Cancer 2020; 12 (1) :24-28
URL: http://ijbc.ir/article-1-928-en.html
URL: http://ijbc.ir/article-1-928-en.html
Ali Dideban1 
, Ensiyeh Seyedrezazadeh2 , Akbar Sharifi2 , Bahareh Abd-Nikfarjam3 , Morteza Sadeghi * 4
, Ensiyeh Seyedrezazadeh2 , Akbar Sharifi2 , Bahareh Abd-Nikfarjam3 , Morteza Sadeghi * 4
1- uman Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4- uman Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , ms.sadeghi@yahoo.com
2- Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
4- uman Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , ms.sadeghi@yahoo.com
Abstract: (3308 Views)
Background: Lung cancer is the first cause of cancer deaths worldwide. Polymorphisms in microRNAs genes affect their structure and their attachment to target genes. The purpose of the present study was to investigate the association of miR-146a rs2910164 polymorphism with the risk of non-small cell lung cancer (NSCLC) in Iranian patients.
Methods: This case-control study was performed among 103 patients with lung cancer and 100 healthy controls. The genotyping of miR-146a rs2910164 polymorphism was assayed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and a number of samples were sequenced for final approval.
Results: A significant association was found between rs2910164 polymorphism CG genotype and risk of lung cancer progression in dominant models (CG vs. GG: OR=1.855, CI=1.09-3.33, P=0.03). There was no association between the C allele and frequency of rs2910164C>G polymorphism and risk of lung cancer (C vs. G: OR=1.54, CI=0.97-2.44, P=0.08).
Conclusion: There was a significant association between miR-146a rs2910164 polymorphism and lung cancer in Iranian population. This polymorphism can be considered as a risk factor of non-small cell lung cancer.
Methods: This case-control study was performed among 103 patients with lung cancer and 100 healthy controls. The genotyping of miR-146a rs2910164 polymorphism was assayed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and a number of samples were sequenced for final approval.
Results: A significant association was found between rs2910164 polymorphism CG genotype and risk of lung cancer progression in dominant models (CG vs. GG: OR=1.855, CI=1.09-3.33, P=0.03). There was no association between the C allele and frequency of rs2910164C>G polymorphism and risk of lung cancer (C vs. G: OR=1.54, CI=0.97-2.44, P=0.08).
Conclusion: There was a significant association between miR-146a rs2910164 polymorphism and lung cancer in Iranian population. This polymorphism can be considered as a risk factor of non-small cell lung cancer.
: Original Article |
Subject:
Genetics
Received: 2019/08/19 | Accepted: 2020/01/28 | Published: 2020/05/2
Received: 2019/08/19 | Accepted: 2020/01/28 | Published: 2020/05/2
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