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:: Volume 12, Issue 1 (March 2020 2020) ::
IJBC 2020, 12(1): 29-33 Back to browse issues page
Multiple Cerebral Juvenile Xanthogranuloma; a Case Report
Sima Fallah-Arzpeima, Bahram Darbandi, Afagh Hassanzadeh Rad, Mohamad Haghani Dogahe, Parham Niyasti, Adel Baghersalimi *
Assistant Professor of pediatric hematology and oncology, Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (172 Views)
Juvenile xanthogranuloma (JXG), is the most common form of non-Langerhans cell histiocytosis. It is a rare and usually benign, monoclonal proliferative disorder of histiocytic cells. The occurrence of multiple brain lesions is extremely rare. Due to the rarity of CNS disease, the preferred treatment and overall prognosis of these patients remain unclear. In this case report, authors present their experience about a patient with isolated multiple cerebral JXG which yields considerable outcomes. The patient was an eleven-year-old boy with anorexia and recurrent vomiting. Brain MRI demonstrated multiple lesions involving right lateral ventricle wall and periventricular white matter, the right side of splenium, mammillary body and tuber cinereum, fourth ventricle floor and roof, and cerebellar tonsil. After initial response to chemotherapy, the lesions recurred and radiotherapy was done. Consequent to good response after radiotherapy and despite the occurrence of a seizure attack, long term follow-up showed the marked resolution of the lesions and a good general status. 
Keywords: Juvenile xanthogranuloma, Child, Magnetic resonance imaging, Radiotherapy, Follow-Up
Full-Text [PDF 1572 kb]   (34 Downloads)    
: case report | Subject: Pediatric Hematology & Oncology
Received: 2019/09/17 | Accepted: 2020/04/19 | Published: 2020/05/2
* Corresponding Author Address: Rasht, Iran
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Fallah-Arzpeima S, Darbandi B, Hassanzadeh Rad A, Haghani Dogahe M, Niyasti P, Baghersalimi A. Multiple Cerebral Juvenile Xanthogranuloma; a Case Report. IJBC. 2020; 12 (1) :29-33
URL: http://ijbc.ir/article-1-937-en.html


Volume 12, Issue 1 (March 2020 2020) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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