[Home ] [Archive]    
:: Home :: About Journal :: Registration :: Article Submission :: Contact us :: Site Map ::
:: Volume 12, Issue 1 (March 2020 2020) ::
IJBC 2020, 12(1): 24-28 Back to browse issues page
Association of MicroRNA-146a rs2910164 Polymorphism and Lung Cancer in Iranian Population: A Case-Control Study
Ali Dideban, Ensiyeh Seyedrezazadeh, Akbar Sharifi, Bahareh Abd-Nikfarjam, Morteza Sadeghi *
uman Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (805 Views)
Background: Lung cancer is the first cause of cancer deaths worldwide. Polymorphisms in microRNAs genes affect their structure and their attachment to target genes. The purpose of the present study was to investigate the association of miR-146a rs2910164 polymorphism with the risk of non-small cell lung cancer (NSCLC) in Iranian patients. 
Methods: This case-control study was performed among 103 patients with lung cancer and 100 healthy controls. The genotyping of miR-146a rs2910164 polymorphism was assayed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and a number of samples were sequenced for final approval. 
Results: A significant association was found between rs2910164 polymorphism CG genotype and risk of lung cancer progression in dominant models (CG vs. GG: OR=1.855, CI=1.09-3.33, P=0.03). There was no association between the C allele and frequency of rs2910164C>G polymorphism and risk of lung cancer (C vs. G: OR=1.54, CI=0.97-2.44, P=0.08). 
Conclusion: There was a significant association between miR-146a rs2910164 polymorphism and lung cancer in Iranian population. This polymorphism can be considered as a risk factor of non-small cell lung cancer.
Keywords: MicroRNA-146a, Polymorphism, Lung cancer, Risk factor
Full-Text [PDF 703 kb]   (160 Downloads)    
: Research | Subject: Genetics
Received: 2019/08/19 | Accepted: 2020/01/28 | Published: 2020/05/2
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Dideban A, Seyedrezazadeh E, Sharifi A, Abd-Nikfarjam B, Sadeghi M. Association of MicroRNA-146a rs2910164 Polymorphism and Lung Cancer in Iranian Population: A Case-Control Study. IJBC. 2020; 12 (1) :24-28
URL: http://ijbc.ir/article-1-928-en.html

Volume 12, Issue 1 (March 2020 2020) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
Persian site map - English site map - Created in 0.04 seconds with 29 queries by YEKTAWEB 4218