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جلد 4 شماره 4 صفحات 169-178 برگشت به فهرست نسخه ها
Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
چکیده:   (6713 مشاهده)
Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizing enzymes (CYP family, NQO1, GST), enzymes involved in folate metabolism (MTHFR, MTRR, SHMT, TS), and DNA repair enzymes (RAD51, XRCC1, ERCC2), chromosome translocation and epigenetic events discussed in this review, can be introduced as candidate alterations in acute lymphoblastic leukemia. Keyword: Acute lymphoblastic leukemia, genetic predisposition to disease, DNA repair enzymes, translocation, review.
متن کامل [PDF 555 kb]   (1643 دریافت)    
: پژوهشي | موضوع مقاله: Pediatric Hematology & Oncology
دریافت: ۱۳۹۰/۱۰/۱۸ | پذیرش: ۱۳۹۱/۱/۲۱ | انتشار: ۱۳۹۱/۱۲/۲۴
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Safaei A, Zaker F. Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia. IJBC. 2012; 4 (4) :169-178
URL: http://ijbc.ir/article-1-386-fa.html

Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia. مجله خون و سرطان ايران. 1391; 4 (4) :169-178

URL: http://ijbc.ir/article-1-386-fa.html



دوره 4، شماره 4 - ( 4-1391 ) برگشت به فهرست نسخه ها
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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