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:: Volume 9, Number 1 (March 2017) ::
IJBC 2017, 9(1): 18-23 Back to browse issues page
Clinicopathological Features of Non-metastatic Triple Negative Breast Cancer
Safa Najafi, Hamid Reza Mozaffari, Masoud Sadeghi *
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (211 Views)

Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world.
Methods: In a retrospective study, 119 women with TNBC based on the criteria were analyzed in this study during 2007-2015. A number of clinicopathological variables, OS and DFS were determined in all patients. The mean follow-up was 38 months, which 6 patients lost to follow-up and 16 died of the disease and therefore were censored from the study. 
Results: The mean age at diagnosis was 44.9 years (range: 21-85 years). 31.9% were older than 50 years. The 2- and 5-years OS rates were 96% and 88.1%, respectively; whereas, the 2- and 5-years DFS rates were 87% and 74.1%, respectively. Right breast tumor and lymph node involvement were more common in patients younger than 50 years, but vascular invasion was more observed in patients aged ≥50 years. There was no significant difference between menopause status, age and Ki-67 index for OS or DFS. 
Conclusion: The prevalence of TNBC was more common in women younger than 50 years. Ki-67 index, menopausal status and age could contribute to prognosis and survival of patients.

Keywords: Breast cancer, Overall survival, Disease free survival, Prognostic factors, Triple negative, Estrogen receptor, Progesterone receptor, HER2 receptors
Full-Text [PDF 1257 kb]   (117 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Received: 2016/11/16 | Accepted: 2017/03/4 | Published: 2017/04/3
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Najafi S, Mozaffari H R, Sadeghi M. Clinicopathological Features of Non-metastatic Triple Negative Breast Cancer. IJBC. 2017; 9 (1) :18-23
URL: http://ijbc.ir/article-1-698-en.html
Volume 9, Number 1 (March 2017) Back to browse issues page
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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