Volume 10, Issue 1 ( March 2018 2018)                   Iranian Journal of Blood and Cancer 2018, 10(1): 28-30 | Back to browse issues page

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Karimi M, Zarei T, Pishdad P. Extramedullary Hematopoiesis in a Patient with Transfusion Dependent Beta-Thalassemia Presenting with Cord Compression. Iranian Journal of Blood and Cancer 2018; 10 (1) :28-30
URL: http://ijbc.ir/article-1-766-en.html
Extramedullary Hematopoiesis in a Patient with Transfusion Dependent Beta-Thalassemia Presenting with Cord Compression
Mehran Karimi *1 , Tahereh Zarei2 , Parisa Pishdad3
1- Hematology Research Center, Shiraz University of Medical Sciences, Shiraz ,Iran , mkarimi820@gmail.com
2- Hematology Research Center, Shiraz University of Medical Sciences
3- Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (4814 Views)
Extramedullary hematopoiesis (EMH) is a physiological compensatory phenomenon occurring in many hemolytic anemias including thalassemia. Besides transfusion, radiotherapy, surgery or a combination of these modalities, hydroxyurea (HU) as an optimal treatment has been described occasionally. We described a case of beta-thalassemia major who has been on regular blood transfusion and developed EMH that was treated with HU combined with radiotherapy.
EMH should also be considered in thalassemia major patients, although it is more common in non-transfusion dependent thalassemia patients. HU combined with low dose radiotherapy along with regular blood transfusion are suggested as good treatment options for patients with EMH.
Keywords: Extramedullary hematopoiesis, Beta-thalassemia major, Hydroxyurea, Radiotherapy, Blood transfusion
Full-Text [PDF 1099 kb]   (3036 Downloads)    
: Case report | Subject: Adults Hematology & Oncology
Received: 2017/10/22 | Accepted: 2018/03/17 | Published: 2018/05/8
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