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:: دوره 10، شماره 4 - ( 9-1397 ) ::
جلد 10 شماره 4 صفحات 114-116 برگشت به فهرست نسخه ها
Methylation Status of SMG1 Gene Promoter in Multiple Myeloma
چکیده:   (79 مشاهده)
Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma.
Methods: Methylation status of SMG1 promoter in 9 patients with multiple myeloma and 4 healthy subjects as control was determined by Methylation-specific PCR (MSP) method.
Results: SMG1 promoter in all myeloma patients was hemi-methylated. Meanwhile, in healthy subjects, two cases were hemi-methylated and the other two were normal.
Conclusion: The results of this study indicated that the prevalence of SMG1 promoter methylation in patients with multiple myeloma was higher than general population which could be important in understanding the pathogenesis of the disease.
متن کامل [PDF 634 kb]   (53 دریافت)    
: پژوهشي | موضوع مقاله: Adults Hematology & Oncology
دریافت: ۱۳۹۷/۶/۱۶ | پذیرش: ۱۳۹۷/۸/۱۹ | انتشار: ۱۳۹۷/۱۰/۱۵
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Gholipour H, Abroun S, Noruzinia M, Ghaffari S, Maali A, Azad M. Methylation Status of SMG1 Gene Promoter in Multiple Myeloma . IJBC. 2018; 10 (4) :114-116
URL: http://ijbc.ir/article-1-826-fa.html

Methylation Status of SMG1 Gene Promoter in Multiple Myeloma . مجله خون و سرطان ايران. 1397; 10 (4) :114-116

URL: http://ijbc.ir/article-1-826-fa.html



دوره 10، شماره 4 - ( 9-1397 ) برگشت به فهرست نسخه ها
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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