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Efficacy of Rituximab in the Treatment of Plasma Exchange Refractory Thrombotic Thrombocytopenic Purpura
Alireza Sadeghi , Farzaneh Ashrafi , Arman Sourani *
Student Research Committee, School of medicine, Isfahan University of Medical sciences, Isfahan, Iran
Abstract:   (18 Views)
Background: Rituximab can induce a durable remission in plasma exchange refractory thrombotic thrombocytopenic purpura (TTP). Timing of Rituximab infusion in combination with plasma exchange (PE) and long term follow-up for probable side effects of such treatment is still lacking.
Methods: This study was conducted among 10 patients with plasma exchange refractory TTP. According to the study designation, first PE was performed within 36-48 hours after first dose of rituximab.
Results: Eight of ten (80%) patients received 1 course of rituximab. Two of ten (20%) patients received another course of rituximab due to relapse. Repsonse rate (RR) to rituximab in combination with plasma exchange, was 90%. Overall Survival of the patients was 90% and 1 and 5-year relapse free survival rate (RFS) was 90% and 83%, respectively. One of the patients expired due to Systemic Lupus Erythematosus flare up.
Conclusion: According to this study, treatment of refractory TTP with rituximab in combination with PE could be effective.
Iranian Registry of Clinical Trials: IRCT2017012232125N1
Keywords: Rituximab, Thrombotic thrombocytopenic purpura, Plasma exchange, Refractory
Full-Text [PDF 725 kb]   (5 Downloads)    
: Research | Subject: Adults Hematology & Oncology
Received: 2018/04/16
* Corresponding Author Address: Department of Hematology-Oncology, Alzahra Teaching Hospital, Isfahan, Iran.
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مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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