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:: دوره 10، شماره 3 - ( 6-1397 ) ::
جلد 10 شماره 3 صفحات 87-91 برگشت به فهرست نسخه ها
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چکیده:   (167 مشاهده)
Background: Rituximab can induce a durable remission in plasma exchange refractory thrombotic thrombocytopenic purpura (TTP). Timing of Rituximab infusion in combination with plasma exchange (PE) and long term follow-up for probable side effects of such treatment is still lacking.
Methods: This study was conducted among 10 patients with plasma exchange refractory TTP. According to the study designation, first PE was performed within 36-48 hours after first dose of rituximab.
Results: Eight of ten (80%) patients received 1 course of rituximab. Two of ten (20%) patients received another course of rituximab due to relapse. Repsonse rate (RR) to rituximab in combination with plasma exchange, was 90%. Overall Survival of the patients was 90% and 1 and 5-year relapse free survival rate (RFS) was 90% and 83%, respectively. One of the patients expired due to Systemic Lupus Erythematosus flare up.
Conclusion: According to this study, treatment of refractory TTP with rituximab in combination with PE could be effective.
Iranian Registry of Clinical Trials: IRCT2017012232125N1
متن کامل [DOCX 137 kb]   (91 دریافت)    
: پژوهشي | موضوع مقاله: Adults Hematology & Oncology
دریافت: ۱۳۹۷/۱/۲۷ | پذیرش: ۱۳۹۷/۸/۲ | انتشار: ۱۳۹۷/۸/۲
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Sadeghi A, Ashrafi F, Sourani A. Efficacy of Rituximab in the Treatment of Plasma Exchange Refractory Thrombotic Thrombocytopenic Purpura. IJBC. 2018; 10 (3) :87-91
URL: http://ijbc.ir/article-1-799-fa.html

-. مجله خون و سرطان ايران. 1397; 10 (3) :87-91

URL: http://ijbc.ir/article-1-799-fa.html



دوره 10، شماره 3 - ( 6-1397 ) برگشت به فهرست نسخه ها
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
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