Volume 15, Issue 4 (September 2023 2023)                   Iranian Journal of Blood and Cancer 2023, 15(4): 293-303 | Back to browse issues page

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E. Khamseh M, Malek M, Hashemi-madani N, Ghassemi F, Rahimian N, Ziaee A, et al . Guideline for the diagnosis and treatment of diabetes mellitus in patients with transfusion-dependent thalassemia. Iranian Journal of Blood and Cancer 2023; 15 (4) :293-303
URL: http://ijbc.ir/article-1-1424-en.html
Guideline for the diagnosis and treatment of diabetes mellitus in patients with transfusion-dependent thalassemia
Mohammad E. Khamseh1 , Mojtaba Malek2 , Nahid Hashemi-madani1 , Fariba Ghassemi3 , Neda Rahimian1 , Amir Ziaee3 , Mohammad Reza Foroughi-Gilvaee3 , Pooya Faranoush3 , Negin Sadighnia3 , Ali Elahinia3 , Mohammad Reza Rezvany3 , Vahid Saeedi1 , Mohammad Faranoush * 4
1- Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
2- Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
3- Pediatric Growth and Development Research Center, Iran University of medical sciences, Tehran-Iran
4- Pediatric Growth and Development Research Center, Iran University of medical sciences, Tehran-Iran , faranoush47@gmail.com
Abstract:   (856 Views)

Thalassemia major hemoglobinopathy requires regular blood transfusions, often leading to iron overload due to repeated transfusions and increased intestinal iron absorption. The association between thalassemia major and metabolic complications, including diabetes and metabolic syndrome, has been recognized due to iron overload, insulin secretion impairment, insulin resistance, hepatic dysfunction, and other endocrine complications. These hormonal imbalances can also influence glucose metabolism and contribute to the development of metabolic syndrome. It's essential for individuals with thalassemia major to undergo regular monitoring of their glucose metabolism, including periodic assessments of fasting blood glucose, oral glucose tolerance tests, and measurement of Fructosamine. Early detection and management of diabetes and metabolic syndrome in thalassemia major patients are crucial to minimize complications and optimize overall health. Medical management may involve a combination of regular blood transfusions, iron chelation therapy to reduce iron overload, lifestyle modifications such as a healthy diet and physical activity, and, if needed, pharmacological interventions for glycemic control. Close collaboration between hematologists and endocrinologists is often necessary to provide comprehensive care for individuals with thalassemia major and metabolic complications. 

Keywords: Thalassemia, Blood transfusion, Diabetes
Full-Text [PDF 3661 kb]   (523 Downloads)    
: Original Article | Subject: Adults Hematology & Oncology
Received: 2023/07/26 | Accepted: 2023/09/21 | Published: 2023/09/27
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