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Volume 17, Issue 4 (December-2025 2025)
Iranian Journal of Blood and Cancer 2025, 17(4): 14-19 |
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Kumar Prajapati S, Jyotishi C, Vaghasiya D, Gupta R. A Novel Chromosomal Translocation t(X;10) in a Pediatric Acute Myeloid Leukemia Patient Complicated by Subarachnoid Intraventricular Hemorrhage. Iranian Journal of Blood and Cancer 2025; 17 (4) :14-19
URL: http://ijbc.ir/article-1-1804-en.html
URL: http://ijbc.ir/article-1-1804-en.html
1- Parul Institute of Applied Sciences, Parul University, Post Limda, Waghodia Road, Vadodara, Gujarat, India.
2- Blood Cancer Institute, Surat, Gujarat, India.
3- Parul Institute of Applied Sciences, Parul University, Post Limda, Waghodia Road, Vadodara, Gujarat, India. & Research and Development Cell, Parul University, Post Limda, Waghodia Road, Gujarat, India. ,reeshu.gupta25198@paruluniversity.ac.in
2- Blood Cancer Institute, Surat, Gujarat, India.
3- Parul Institute of Applied Sciences, Parul University, Post Limda, Waghodia Road, Vadodara, Gujarat, India. & Research and Development Cell, Parul University, Post Limda, Waghodia Road, Gujarat, India. ,
Abstract: (261 Views)
Background: Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem cells, seen rarely in children. Intraventricular hemorrhage (IVH) is an uncommon but often fatal complication of AML, and its management is difficult because it requires balancing intensive chemotherapy with supportive care for bleeding.
Case Presentation: We report the case of an 11-year-old child with newly diagnosed AML who presented with fever, neurological deterioration, and respiratory distress, and was found to have subarachnoid intraventricular hemorrhage.
Cytogenetic Findings: Bone marrow karyotyping demonstrated a novel translocation involving chromosomes X and 10 with breakpoints at Xq13 and 10p11.2 or 46,XY,t(X;10)(q13;p11.2). This was confirmed by fluorescence in situ hybridization (FISH). Other recurrent AML-associated abnormalities were not detected.
Clinical Course: The patient received antifibrinolytics, platelet support, anticonvulsants, and external ventricular drainage. Flow cytometry of bone marrow aspirate showed 85% blasts expressing CD34, CD117, HLA-DR, CD13, and CD33, consistent with AML. The patient developed refractory shock and cardiac arrest, and death occurred before leukemia-directed treatment could be initiated.
Conclusions: This case describes a rare cytogenetic abnormality in AML associated with IVH. A direct causal relationship cannot be inferred from a single report; however, documenting such rare findings adds to the body of knowledge and may help in future studies exploring genetic factors and clinical outcomes in AML.
Case Presentation: We report the case of an 11-year-old child with newly diagnosed AML who presented with fever, neurological deterioration, and respiratory distress, and was found to have subarachnoid intraventricular hemorrhage.
Cytogenetic Findings: Bone marrow karyotyping demonstrated a novel translocation involving chromosomes X and 10 with breakpoints at Xq13 and 10p11.2 or 46,XY,t(X;10)(q13;p11.2). This was confirmed by fluorescence in situ hybridization (FISH). Other recurrent AML-associated abnormalities were not detected.
Clinical Course: The patient received antifibrinolytics, platelet support, anticonvulsants, and external ventricular drainage. Flow cytometry of bone marrow aspirate showed 85% blasts expressing CD34, CD117, HLA-DR, CD13, and CD33, consistent with AML. The patient developed refractory shock and cardiac arrest, and death occurred before leukemia-directed treatment could be initiated.
Conclusions: This case describes a rare cytogenetic abnormality in AML associated with IVH. A direct causal relationship cannot be inferred from a single report; however, documenting such rare findings adds to the body of knowledge and may help in future studies exploring genetic factors and clinical outcomes in AML.
: Case report |
Subject:
Genetics
Received: 2025/10/26 | Accepted: 2025/12/7 | Published: 2025/12/30
Received: 2025/10/26 | Accepted: 2025/12/7 | Published: 2025/12/30
References
1. Tseng S, Lee ME, Lin PC. A Review of Childhood Acute Myeloid Leukemia: Diagnosis and Novel Treatment. Pharmaceuticals (Basel). 2023;16(11). [DOI:10.3390/ph16111614]
2. (2022) T-CY. Pediatric Acute Myeloid Leukemia (AML) Classifications. . Pediatr Ther. 2022;S5(002):1.
3. Meng CY, Noor PJ, Ismail A, Ahid MF, Zakaria Z. Cytogenetic Profile of de novo Acute Myeloid Leukemia Patients in Malaysia. Int J Biomed Sci. 2013;9(1):26-32. [DOI:10.59566/IJBS.2013.9026]
4. Kumar CC. Genetic abnormalities and challenges in the treatment of acute myeloid leukemia. Genes Cancer. 2011;2(2):95-107. [DOI:10.1177/1947601911408076]
5. Rorvik SD, Torkildsen S, Bruserud O, Tvedt THA. Acute myeloid leukemia with rare recurring translocations-an overview of the entities included in the international consensus classification. Ann Hematol. 2024;103(4):1103-19. [DOI:10.1007/s00277-024-05680-5]
6. Chen G, Zhou W, Gong D, Li Y, Huang S, Wang N, et al. Loss of X chromosome predicts favorable prognosis in female patients with t(8;21) acute myeloid leukemia. Leuk Lymphoma. 2020;61(5):1168-77. [DOI:10.1080/10428194.2019.1709836]
7. Abla O, Dror Y, Shago M. Translocation (X;10) in a child with therapy-related acute myeloid leukemia following chemotherapy for Ewing's Sarcoma. Cancer Genet Cytogenet. 2007;178(2):168-9. [DOI:10.1016/j.cancergencyto.2007.07.007]
8. Manabe M, Tanizawa N, Nanno S, Hagiwara Y, Asada R, Koh KR. A rare der(10)t(X;10)(p11.2;p11.2) in an elderly patient with therapy-related acute myelomonocytic leukemia. EJHaem. 2022;3(1):256-8. [DOI:10.1002/jha2.360]
9. Bennour A, Sennana H, Zaier M, Ouahchi I, Mrad Z, Ben Youssef Y, et al. Translocation t(X;10)(p10;p10): a rare chromosomal abnormality in a new born female with acute myeloid leukemia. Med Oncol. 2012;29(2):1134-6. [DOI:10.1007/s12032-011-9908-x]
10. Heim S, Bekassy AN, Garwicz S, Heldrup J, Kristoffersson U, Mandahl N, et al. Bone marrow karyotypes in 94 children with acute leukemia. Eur J Haematol. 1990;44(4):227-33. [DOI:10.1111/j.1600-0609.1990.tb00384.x]
11. Lelong F, Chretien P, Jouault H, Bayani N, Bernaudin F, Lemerle S. A case of peroxidase-positive acute leukaemia expressing only T lineage lymphoid markers. Br J Haematol. 1994;86(1):195-7. [DOI:10.1111/j.1365-2141.1994.tb03276.x]
12. Wong KF, Hayes KJ, Huh YO, Albitar M, Glassman AB. Translocation (X;10)(p10;p10): A rare but nonrandom chromosomal abnormality in acute leukemia of myeloid differentiation. Cancer Genet Cytogenet. 1996;86(2):153-5. [DOI:10.1016/0165-4608(95)00206-5]
13. Chen CY, Tai CH, Tsay W, Chen PY, Tien HF. Prediction of fatal intracranial hemorrhage in patients with acute myeloid leukemia. Ann Oncol. 2009;20(6):1100-4. [DOI:10.1093/annonc/mdn755]
14. Huang N, Zhou J, Lu W, Luo L, Yuan H, Pan L, et al. Characteristics and clinical evaluation of X chromosome translocations. Mol Cytogenet. 2023;16(1):36. [DOI:10.1186/s13039-023-00669-7]
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