Sun, Nov 1, 2026
[Archive]
Volume 18, Issue 3 (September-2026 2026)
Iranian Journal of Blood and Cancer 2026, 18(3): 59-63 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Bordbar M, Sedghi R, Bordbar S. Leukemia Cutis as the Initial Presentation of B-Cell Acute Lymphoblastic Leukemia: A Case Report and review of the literature. , Iranian Journal of Blood and Cancer. 2026; 18 (3) :59-63
URL: http://ijbc.ir/article-1-1905-en.html
URL: http://ijbc.ir/article-1-1905-en.html
1- Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract: (15 Views)
Background: Leukemia cutis (LC) is uncommon in children and may precede recognition of systemic leukemia. A solitary scalp mass with a normal blood count can be mistaken for a benign lesion.
Case Presentation: A 12-year-old girl had a six-month history of a right frontoparietal scalp mass initially considered a lipoma. The lesion was firm, alopecic, and approximately 2 × 2 cm. Complete blood count and peripheral smear were unremarkable. Skin biopsy showed a TdT-, CD19-, CD10-, CD34-, and PAX5-positive precursor B-cell infiltrate with a high Ki-67 index. Bone marrow contained 30.8% blasts with a B-lineage immunophenotype, establishing B-cell acute lymphoblastic leukemia (B-ALL). The scalp lesion nearly regressed after induction therapy. Although morphologic remission was achieved at end of induction, measurable residual disease (MRD) was 2.05%; MRD declined to 0.0066% at end of consolidation and was 0.0033% at last reported assessment.
Conclusion: Persistent or enlarging scalp lesions in children warrant tissue diagnosis even when peripheral blood findings are normal.
Case Presentation: A 12-year-old girl had a six-month history of a right frontoparietal scalp mass initially considered a lipoma. The lesion was firm, alopecic, and approximately 2 × 2 cm. Complete blood count and peripheral smear were unremarkable. Skin biopsy showed a TdT-, CD19-, CD10-, CD34-, and PAX5-positive precursor B-cell infiltrate with a high Ki-67 index. Bone marrow contained 30.8% blasts with a B-lineage immunophenotype, establishing B-cell acute lymphoblastic leukemia (B-ALL). The scalp lesion nearly regressed after induction therapy. Although morphologic remission was achieved at end of induction, measurable residual disease (MRD) was 2.05%; MRD declined to 0.0066% at end of consolidation and was 0.0033% at last reported assessment.
Conclusion: Persistent or enlarging scalp lesions in children warrant tissue diagnosis even when peripheral blood findings are normal.
: Case report |
Subject:
Pediatric Hematology & Oncology
Received: 2026/08/19 | Accepted: 2026/09/23 | Published: 2026/09/30
Received: 2026/08/19 | Accepted: 2026/09/23 | Published: 2026/09/30
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
- Iranian Journal of Blood and Cancer
- Journal Tel: +989369936116
- Publisher Tel: +982122275917
- Mail: Info@ijbc.ir
