[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره كنفرانس :: ثبت نام :: ارسال مقاله :: برقراري ارتباط :: راهنماي پايگاه ::
:: دوره 13، شماره 1 - ( 11-1399 ) ::
جلد 13 شماره 1 صفحات 1-5 برگشت به فهرست نسخه ها
Comparison of Secreted Frizzled-Related Protein -4 & -5 Promoter Methylation in Patients with Acute Myeloblastic Leukemia and Healthy Individuals
چکیده:   (512 مشاهده)
Background: DNA methylation patterns are often changed in cancer cells. Many of the tumor inhibitor genes are silenced by methylation, such as CDKN2B, p73, and the suppressor of cytokine signaling in patients with acute myeloblastic leukemia (AML). Secreted frizzled-related protein -4 and -5 (SFRP4, 5) are negative regulators of the Wnt signaling pathway. We aimed to evaluate the methylation status of SFRP4 and SFRP5 genes in patients with AML.
Methods: Blood samples were isolated from 60 patients with AML and 30 healthy controls. DNA was exploited, treated with sodium bisulfite, and tested utilizing methylation-specific polymerase chain reaction with specific primers for methylated and unmethylated sequences of the SFRP4 and SFRP5 genes.
Results: The frequency of unfit hypermethylation of SFRP4 and SFRP5 genes in patients with AML was characterized to be 50% (30/60) and 40% (24/60), respectively. Moreover, for all the subjects in the control group, methylation of SFRP4 and SFRP5 genes was negative. The spread of SFRP4 and SFRP5 promoter methylation in patients with AML was higher than the control population.
Conclusion: Hypermethylation was seen in SFRP4 and SFRP5 genes in patients with AML. 
متن کامل [PDF 581 kb]   (205 دریافت)    
: پژوهشي | موضوع مقاله: Adults Hematology & Oncology
دریافت: 1399/1/8 | پذیرش: 1399/10/15 | انتشار: 1400/3/2
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghaffari K, Ghasemi A, Mohammadi M, Abbasian S. Comparison of Secreted Frizzled-Related Protein -4 & -5 Promoter Methylation in Patients with Acute Myeloblastic Leukemia and Healthy Individuals. IJBC. 2021; 13 (1) :1-5
URL: http://ijbc.ir/article-1-988-fa.html

Comparison of Secreted Frizzled-Related Protein -4 & -5 Promoter Methylation in Patients with Acute Myeloblastic Leukemia and Healthy Individuals. مجله خون و سرطان ايران. 1399; 13 (1) :1-5

URL: http://ijbc.ir/article-1-988-fa.html



دوره 13، شماره 1 - ( 11-1399 ) برگشت به فهرست نسخه ها
مجله ی خون و سرطان ایران Iranian Journal of Blood and Cancer
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4319