Showing 1 results for Fracture.
Dr Mojtaba Malek, Dr Mohammad E. Khamseh, Dr Pooya Faranoush, Dr Nahid Hashemi-Madani, Dr Neda Rahimian, Dr Fariba Ghassemi, Dr Mohammad Reza Foroughi-Gilvaee, Dr Negin Sadighnia, Dr Ali Elahinia, Dr Mohammad Reza Rezvany, Dr Dorsa Fallah Azad, Dr Mohammad Faranoush,
Volume 16, Issue 1 (3-2024)
Abstract
The health-related quality of life and management of patients with thalassemia has significantly improved in recent years due to standard treatments and safe blood transfusions with effective chelation therapy to reduce iron overload. Transfusion-dependent thalassemia is associated with numerous skeletal abnormalities, including osteoporosis, which is a significant cause of morbidity in these patients. Osteoporosis is characterized by low bone mass and an increased risk of fractures, particularly in the lumbar spine and in patients with extramedullary hematopoiesis. It remains a significant problem in adult transfusion-dependent thalassemia, particularly in patients under chelation therapy. A fracture history is significantly associated with lower Dual-Energy X-ray Absorptiometry (DEXA) T/Z scores, which decrease with age. Improved management and modern treatments for transfusion-dependent thalassemia patients with osteoporosis should be prioritized to prevent bone fractures and improve quality of life in older age.
