Showing 5 results for Infant
H Rezvanian, H Samaie, M Faranoush,
Volume 3, Issue 2 (1-2011)
Abstract
Background:Intraventricular hemorrhage is the most common intracranial hemorrhage in premature infants. The
objective of this study was to investigate the relationship between intraventricular hemorrhage and blood leukocyte
count.
Materials and Methods:This was a cross-sectional simple sampling study conducted from the beginning of 2006 to
2010 in Ali-Asghar Children’s Hospital. Inclusion criteria were birth weight less than 1500 grams, and at least one
cranial ultrasound performed in the first 7 days. The CBC was taken one hour after first entering the NICU. WBC count
greater than 25000 cell/ml was considered as leukocytosis and ANC greater than 15000 as neutrophilia.
Results:Two hundred neonates were included in the study. Intraventricular hemorrhage was reported in 59 patients
(29.5%). There was significant correlation between Intraventricular hemorrhage and mechanical ventilation
(P=0.003). Significant correlation was observed between gestational age and WBC count in the first and second
days (P=0.001), and between birth weight and WBC count in the first and second days (P = 0.03). There was also
a correlation between WBC count in the first and second days and the first minutes Apgar score (P = 0.03), and
between the fifth minute Apgar score and the first day WBC count (P=0.005).
Conclusion:Intraventricular hemorrhage incidence was associated with mechanical ventilation and pneumothorax,
but no significant correlation was found with the total peripheral leukocyte count and neutrophil count during
the first 72 hours after the birth. Further studies are needed to confirm the probable role of leukocytosis in the
pathophysiology of intraventricular hemorrhage.
Key Words: Leukocyte, intraventricular, hemorrhage, infant, preterm, complications
Alghasi A, Pedram M, Saki N, Salari F, Jaseb K, Aminasnafi A, Yousefi H, Saki Malehi A, Noroozi F, Moeinzadeh L,
Volume 7, Issue 3 (4-2015)
Abstract
Background: Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer leading to cancer-related death in children. Most infants with ALL harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. Mixed-lineage leukemia-rearrangement (MLL-rearrangement) at 11q23 occurs in at least two-thirds of infants with ALL. The most common MLL rearrangements are t(411)(q21q23)/MLL-AFF1 (AF4) found in approximately 50% of patients.
Methods: Forty children with ALL were enrolled in our study. 11q23 rearrangement and its association with other prognostic factors such as age, sex, initial WBC, organomegaly, immunophenotype, and therapeutic response on the seventh day of induction were studied.
Results: Four patients including three (11.5%) boys and one (7.1%) girl were positive for 11q23 translocation. There was no association between 11q23 rearrangement and sex, age, and initial WBC counts. None of the patients with 11q23 translocation showed blast count less than 5% in the bone marrow on the seventh day of induction (P=0.002).
Conclusion: There was a significant correlation between 11q23 translocation with lack of initial response to chemotherapy.
Keywords: Acute lymphoblastic leukemia, 11q23 translocation, Cytogenetic, Infant acute lymphoblastic leukemia, prognosis, Induction failure
Mohammad Naderisorki, Ahmad Mohammadi Ashiani, Zahra Khaffafpour,
Volume 8, Issue 4 (12-2016)
Abstract
Rim Ben Abdelaziz, Fathi Mellouli, Mohamed Tahar Lamouchi, Sana Ben Messaoud, Monia Ben Khaled, Raoudha Doghri, Hela Boudabous, Amel Ben Chehida, Hatem Azzouz, Mohamed Bejaoui, Neji Tebib,
Volume 10, Issue 1 (3-2018)
Abstract
Pancytopenia in childhood can be caused by a variety of underlying diseases including hematological and non-hematological entities. Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism. No association between PKU and pancytopenia has ever been reported. We report the first case of PKU revealed by a pancytopenia at presentation. The patient was an infant girl born to healthy non-consanguineous parents with unremarkable family history. A hereditary metabolic disease workup was performed due to the presence of unexplained hematological features and a global developmental delay. Plasma aminoacid profile by thin-layer chromatography showed elevation of phenylalanine and urine organic acid chromatography showed accumulation of metabolites of phenylalanine; whereas, methylmalonic acid or other abnormal organic acids were not found. This is the first case of untreated PKU associated with pancytopenia who improved with low-phenylalanine diet.
Jose Arriola-Montenegro, Pedro Guerra Canchari, Patricia Cabanillas-Lozada, Pamela Contreras-Chavez, Liliana Arriola-Montenegro, Karina Ordaya-Gonzales, Marilin Sabogal-Deza,
Volume 12, Issue 3 (10-2020)
Abstract
Hemangiomas are defined as soft tissue lesions in the maxillofacial or oral region. Hemangiomas of salivary glands constitute 30% of the non-epithelial tumors in major salivary glands. Benign tumors in salivary glands are located 85% in parotid gland and 13% in submandibular gland. We present a case of submandibular hemangioma in an infant patient that had some complications and a challenging diagnosis. A 3- month-old female patient presented a giant hemangioma located in the submandibular, preauricular and right malar region with purplish color that during hospitalization had a cardiorespiratory arrest as a severe complication of the disease.
