Volume 14, Issue 3 ( September 2022 2022)                   Iranian Journal of Blood and Cancer 2022, 14(3): 57-70 | Back to browse issues page

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Bahmani F, Azadpour S, Pourbagheri-Sigaroodi A, Bashash D. Plant-derived natural compounds as promising anticancer agents in hematological malignancies. Iranian Journal of Blood and Cancer 2022; 14 (3) :57-70
URL: http://ijbc.ir/article-1-1321-en.html
Plant-derived natural compounds as promising anticancer agents in hematological malignancies
Forouzan Bahmani1 , Shima Azadpour1 , Atieh Pourbagheri-Sigaroodi2 , Davood Bashash * 3
1- Abadan Faculty of Medical Sciences, Abadan, Iran
2- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , David_5980@yahoo.com
Abstract:   (1281 Views)

The latest treatments have improved outcomes for patients with hematological malignancies, but relapse, treatment resistance and particularly side effects still remain as common limitations of these treatments. Given the disadvantages of the existing conventional therapeutic methods, developing more effective drugs with less toxicity and side effects is of paramount importance. Medicinal herbs have historically proven their worth as a pool of potential therapeutic agents for leukemia and lymphoma, and today they still represent a rich source for the recognition of new drug leads. The role of the positive synergistic effects of plant-derived natural products and common chemotherapeutic drugs is also considered as one of the rational reasons for paying attention to the medicinal plants in recent chemoprevention and chemotherapeutic investigations. Noteworthy, targeted delivery of plant-derived natural products via the incorporation of nanoparticles or antibodies would be a major step to improve their bioavailability and then to increase their therapeutic effects. In this study, we reviewed plant-derived agents approved and/or under investigation for hematological malignancies.

Keywords: Plant-derived agents, Medicinal herbs, Natural products, Leukemia, Lymphoma
Full-Text [PDF 1907 kb]   (1111 Downloads)    
: Original Article | Subject: Adults Hematology & Oncology
Received: 2022/10/13 | Accepted: 2022/11/13 | Published: 2022/11/19
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