Volume 14, Issue 3 ( September 2022 2022)                   Iranian Journal of Blood and Cancer 2022, 14(3): 71-83 | Back to browse issues page

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Panahi M, Dehghani Ghorbi M, Amirpour M, Nayebi R, Kuhestani Dehaghi B H. Myelodysplastic Syndromes (MDS); diagnosis, classification, treatment and monitoring. Iranian Journal of Blood and Cancer 2022; 14 (3) :71-83
URL: http://ijbc.ir/article-1-1328-en.html
Myelodysplastic Syndromes (MDS); diagnosis, classification, treatment and monitoring
Maryam Panahi1 , Mahmoud Dehghani Ghorbi2 , Mozhgan Amirpour3 , Reika Nayebi4 , Bentol Hoda Kuhestani Dehaghi * 5
1- Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
2- Department of hematology and oncology, school of allied medical sciences, Shahid Beheshti University of medical sciences, Tehran, Iran
3- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
5- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , Hodakuhestani@gmail.com
Abstract:   (1350 Views)

Due to the neoplastic nature of myelodysplastic syndromes (MDS), they have been renamed as myelodysplastic neoplasms in the World Health Organization (WHO) 2022 classification. These syndromes are heterogeneous groups of myeloid disorders characterized by dysplasia of bone marrow cells, ineffective hematopoiesis, increased apoptosis, peripheral blood cytopenia, and risk of progression to acute myeloid leukemia (AML). The recent progress in understanding the pathogenesis of these diseases is due to the emergence of next-generation sequencing (NGS) and the simultaneous interpretation of
changes in cell morphologies, cytogenetics, and molecular mutations, which have provided the conditions for better classification and determination of efficient prognosis. Based on the Revised International Prognostic Scoring System (IPSS-R) system, MDS treatment approaches were divided into two groups: low-risk MDS, and high-risk MDS. In low-risk MDS, MDS is not the main cause of death, and most of the patients die as a result of cytopenia and the quality of life. Therefore, the goal of treatment approaches in low-risk MDS is to improve the quality of life in patients. However, in patients with high-risk MDS, the possibility of progression to AML is life-threatening. Therefore, clinical decisions aim to improve the course of the disease.
 

Keywords: Myelodysplastic syndromes, Low-risk MDS, High-risk MDS, Cytopenia
Full-Text [PDF 1956 kb]   (1365 Downloads)    
: Review Article | Subject: Adults Hematology & Oncology
Received: 2022/12/14 | Accepted: 2023/01/29 | Published: 2023/02/19
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